Towards peptide formation inside the channels of a new divinylaniline-bridged periodic mesoporous organosilica

Abstract

The first synthesis of a new highly ordered divinylaniline-bridged periodic mesoporous organosilica (PMO) with crystal-like pore walls and further chemical modification of the amino groups on the inner surface of the product by a peptide formation reaction with a chiral amino acid are reported.

Periodic mesoporous organosilicas for advanced applications

“…Fröba and co-workers 91 reported the synthesis of a new, highly ordered divinylaniline-bridged PMO with crystal-like pore walls and the further chemical modification of the amino groups on the inner surface of the product by a peptide formation reaction with a chiral amino acid.…”

Is their potential for post-synthetic brominating reactions on benzene bridged PMOs?

“…However, UKON materials having a wormlike ordering, allow the synthesis of bromobenzene bridged PMOs, which are accessible for further modification reactions. Also the group of Fröba uses this pre-modified approach to synthesize new PMO materials as they have shown in their recent paper [44]. Unless the disadvantages of the pre-modified method, at the moment this seems the most feasible approach to synthesize a wide range of different organic modified PMO and associated applications.…”

One-pot synthesis of hybrid mesoporous xerogels starting with linear polymethylhydrosiloxane and bridged bis-(trimethoxysilyl)ethane

“…Compared with purely silica counterparts or those with pending organic moieties, organic units are one-pot introduced during the synthesis process, instead of during post-synthesis grafting, and homogenously distributed within the network [7]. Therefore, it is favorable that advanced applications such as high-performance stationary phases for chromatography [8,9], efficient catalysts for asymmetric synthesis [10][11][12][13], novel encapsulators for bio-molecules or drugs [14][15][16][17][18][19], selective adsorbents for metal ions or organic substances [20][21][22][23][24][25] and highly assembled precursors for functional porous ceramics [26][27][28] and so on, have been extensively investigated.…”