Towards optimized MRI contrast agents for implant engineering: Clustering and immobilization effects of magnetic nanoparticles

Mues, Benedikt; Buhl, Eva Miriam; Schmitz‐Rode, Thomas

doi:10.1016/j.jmmm.2018.09.119

Cited by 14 publications

(12 citation statements)

References 29 publications

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“…This is due, fundamentally, to the possibility of inducing a magnetic moment in these nanoscopic particles, and their easy ordering through the application of an external magnetic field . This characteristic makes this type of nanomaterial a promising candidate to be used in different applications, which can range from electronics, engineering, optics, and biomedicine, where MNPs have been proposed, for example, as drug magnetic nanovectors, − as heat generators in hyperthermia treatments, − and as contrast agents in magnetic resonance imaging (MRI). − …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

et al. 2020

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Magnetic nanoparticles (MNPs) are one of the most promising candidates for their use as theranostic agents in the biomedical field due to their potential as contrast agents in magnetic resonance imaging (MRI) and also as heat generators in magnetic hyperthermia treatments. However, despite the large number of publications about this topic, just some few systematic studies about the influence of MNPs composition on their theranostic capabilities have been carried out. In this work, we show a detailed methodology for the preparation of highly monodisperse iron oxide-based MNPs with different cobalt, zinc, and manganese doping extents in the superparamagnetic regime. We aim to provide the tools to control the composition of the particles, as well as for their functionalization to make them highly stable in biological-mimicking media. Procedures to measure the capability of the particles as magnetothermal and MRI negative contrast agents as well as to analyze the influence of doping on such properties are also reported. In all experiments, the applied alternating magnetic fields were within the maximum allowed amplitude, frequency, and amplitude·frequency product range for potential validation of the experimental data toward the potential translation of the present MNPs to the clinical practice.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

et al. 2020

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“…Magnetic nanoparticles (NPs) are of great interest for a wide range of disciplines, such as magnetic fluids, catalysis, magnetic energy storage, spintronics, and biomedicine. − In the medical field, they are considered for use in tumor therapy as hyperthermia agents and as site-specific drug delivery agents. − In the field of diagnostic imaging, they are used as contrast agents (CAs) for magnetic resonance imaging (MRI). − The efficiency of CAs is expressed as its relaxivity r 1 or r 2 , which defines the ability to shorten the proton T 1 or T 2 relaxation times per millimole of CA. Commonly used CAs for T 1 -weighted imaging consist of gadolinium (Gd)-based complexes, whereas CAs for T 2 -weighted imaging are iron oxide NPs .…”

Section: Introductionmentioning

confidence: 99%

Size-Tailored Biocompatible FePt Nanoparticles for Dual T₁/T₂ Magnetic Resonance Imaging Contrast Enhancement

Slabu¹,

Wiemer

Steitz³

et al. 2019

Langmuir

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The development of new contrast agents (CAs) for magnetic resonance imaging (MRI) is of high interest, especially because of the increased concerns of patient safety and quick clearance of clinically used gadolinium and iron oxide-based CAs, respectively. Here, a two-step synthesis of superparamagnetic water-soluble iron platinum (FePt) nanoparticles (NPs) with core sizes between 2 and 8 nm for use as CAs in MRI is reported. First, wet-chemical organometallic NPs are synthesized by thermal decomposition in the presence of stabilizing oleic acid and oleylamine. Second, the hydrophobic NPs are coated with an amphiphilic polymer and transferred into aqueous media. Their magnetization values and relaxation rates exceed those published for CAs already used for clinical application. Their saturation magnetization increases with the core size to approximately 82 A·m2/kgFe. For 8 nm NPs, the T 2 relaxivity of approximately 221 (mM·s)−1 is 5 times larger than that for the ferumoxides, and for 6 nm NPs, the T 1 relaxivity of approximately 12 (mM·s)−1 is slightly higher than that of ultrasmall gadolinium oxide NPs. The 6 nm FePt NPs are identified as excellent CAs for both T 1 and T 2 imaging. Most importantly, because of their coating, significantly low cytotoxicity is achieved. FePt NPs prove to be a promising alternative to gadolinium and iron oxide NPs showing high-quality CA characteristics for both T 1- and T 2-weighted images.

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“…This has been observed by others and is attributed to the oriented attachment of primary nanocrystals during the formation of the clusters. 9,16,67 We also explored the effect of other reaction conditions, including the concentrations of polyacrylate (PAA), urea, and iron salts, and compiled our results in Figure S4. PAA provides a surface coating for the nanoclusters, 24,28 while urea ensures a basic reaction environment that promotes forced hydrolysis and ripening of iron oxides.…”

Section: Resultsmentioning

confidence: 99%

“…Others who have studied size dependence for very small clusters have also reported an increase in relaxivity with increasing size. 66,67 Once cluster dimensions exceed 50 nm, however, their contrast decline with increasing diameter (Figure 6). This observation is consistent with studies of larger clusters, which reported a decline in relaxivity with cluster dimension.…”

Section: Resultsmentioning

confidence: 99%

Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications

Xiao

Zhang

Guo

et al. 2020

ACS Appl. Mater. Interfaces

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Multicore iron oxide nanoparticles, also known as colloidal nanocrystal clusters, are magnetic materials with diverse applications in biomedicine and photonics. Here, we examine how both of their characteristic dimensional features, the primary particle and sub-micron colloid diameters, influence their magnetic properties and performance in two different applications. The characterization of these basic size-dependent properties is enabled by a synthetic strategy that provides independent control over both the primary nanocrystal and cluster dimensions. Over a wide range of conditions, electron microscopy and X-ray diffraction reveal that the oriented attachment of smaller nanocrystals results in their crystallographic alignment throughout the entire superstructure. We apply a sulfonated polymer with high charge density to prevent cluster aggregation and conjugate molecular dyes to particle surfaces so as to visualize their collection using handheld magnets. These libraries of colloidal clusters, indexed both by primary nanocrystal dimension (d p ) and overall cluster diameter (D c ), form magnetic photonic crystals with relatively weak size-dependent properties. In contrast, their performance as MRI T 2 contrast agents is highly sensitive to cluster diameter, not primary particle size, and is optimized for materials of 50 nm diameter (r 2 = 364 mM −1 s −1 ). These results exemplify the relevance of dimensional control in developing applications for these versatile materials.

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Towards optimized MRI contrast agents for implant engineering: Clustering and immobilization effects of magnetic nanoparticles

Cited by 14 publications

References 29 publications

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Size-Tailored Biocompatible FePt Nanoparticles for Dual T₁/T₂ Magnetic Resonance Imaging Contrast Enhancement

Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications

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Towards optimized MRI contrast agents for implant engineering: Clustering and immobilization effects of magnetic nanoparticles

Cited by 14 publications

References 29 publications

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Size-Tailored Biocompatible FePt Nanoparticles for Dual T1/T2 Magnetic Resonance Imaging Contrast Enhancement

Libraries of Uniform Magnetic Multicore Nanoparticles with Tunable Dimensions for Biomedical and Photonic Applications

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Product

Resources

About

Size-Tailored Biocompatible FePt Nanoparticles for Dual T₁/T₂ Magnetic Resonance Imaging Contrast Enhancement