Towards optical neuromodulation using nitrogen-doped ultrananocrystalline diamond photoelectrodes

Falahatdoost, Samira; Chambers, Andre; Stacey, Alastair; Prawer, S.; Ahnood, Arman

doi:10.1016/j.surfin.2022.101850

Cited by 4 publications

(16 citation statements)

References 65 publications

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“…33 In our previous research, we utilized Raman spectroscopy, near-edge x-ray absorption fine structure (NEXAFS) measurements, and electrochemical equivalent circuit fitting to elucidate the varying photoresponses of diamond samples. 33 Figure 1b displays the high-resolution carbon 1s XPS spectra of the N-UNCD samples after different annealing periods. An increase in binding energy indicates that more oxygen functional groups were chemically bonded to the surface when the annealing duration increased.…”

Section: Diamond Fabrication and Surfacementioning

confidence: 99%

“…The photoresponses of N-UNCD samples to NIR light were studied using photoelectrochemical measurement, as previously described . These experiments were performed in a saline solution (0.15 M NaCl) by using a three-electrode electrochemical cell connected to a potentiostat (Gamry Interface 1000E).…”

Section: Experimental Sectionmentioning

confidence: 99%

“…In our previous work, we explored the photoelectric properties of N-UNCD, highlighting its response not only to visible light wavelengths but also to the near-infrared (NIR) range. ,, We observed that under NIR illumination, the photoresponse changes depending on the surface termination . For example, in saline solution, hydrogen-terminated N-UNCD shows an illumination induced Faradaic charge transfer mechanism, while oxygen-terminated N-UNCD electrodes predominantly exhibit capacitive photocurrents.…”

Section: Introductionmentioning

confidence: 99%

“…46 In a recent study, we demonstrated oxygen annealing as an effective method to enhance the capacitive photoelectric responses of N-UNCD to NIR illumination. 33 Our findings indicated that photoresponses increased proportionally to the annealing duration, reaching a maximum response when heated in oxygen at 420 °C for 25 h. 33 In this study, we investigate the use of oxygen-annealed N-UNCD as a robust and effective photoelectric platform for wirelessly modulating neuronal development and neurite The process began with incubating glass coverslip controls and diamond substrates in Neurobasal-A medium solution for 12 h. Primary cortical neurons harvested from postnatal rats were seeded onto the samples at a density of 1.4 × 10 5 cells cm −2 . Subsequently, half of the samples from each substrate were exposed to 810-nm NIR light on the first day in vitro (Day 1) at an intensity of 20 mW cm −2 and a frequency of 50 mHz, for 16 h. Cellular structure and morphology of a portion of the cells were assessed on Day 4 via fixation and immunostaining with β-III tubulin and propidium iodide.…”

Section: Introductionmentioning

confidence: 99%

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Control of Neuronal Survival and Development Using Conductive Diamond

Falahatdoost,

Prawer,

Peng

et al. 2024

ACS Appl. Mater. Interfaces

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This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular–substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.

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Section: Diamond Fabrication and Surfacementioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Control of Neuronal Survival and Development Using Conductive Diamond

Falahatdoost,

Prawer,

Peng

et al. 2024

ACS Appl. Mater. Interfaces

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“…The redox reactions of diamond-based PCs should also be considered in simulations such as equivalent circuit modelling. Moreover, due to the semiconducting nature of diamond both the space charge region and electrical double layer contribute to the total capacitance of the electrode, and should be incorporated into capacitance calculations, as has previously been done in equivalent circuit models ( Falahatdoost et al, 2022 ). In the context of optimization of the pore geometry in diamond electrodes, it has been previously suggested that anodized alumina oxide (AAO) templates could be used for easily tuning the pore size and shape, film thickness, and mass loading ( Gao and Nebel, 2016 ).…”

Section: Assisting Supercapacitor Design Through Computational Modellingmentioning

confidence: 99%

Diamond Supercapacitors: Towards Durable, Safe, and Biocompatible Aqueous-Based Energy Storage

et al. 2022

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Durable and safe energy storage is required for the next generation of miniature bioelectronic devices, in which aqueous electrolytes are preferred due to the advantages in safety, low cost, and high conductivity. While rechargeable aqueous batteries are among the primary choices with relatively low power requirements, their lifetime is generally limited to a few thousand charging/discharging cycles as the electrode material can degrade due to electrochemical reactions. Electrical double layer capacitors (EDLCs) possess increased cycling stability and power density, although with as-yet lower energy density, due to quick electrical adsorption and desorption of ions without involving chemical reactions. However, in aqueous solution, chemical reactions which cause electrode degradation and produce hazardous species can occur when the voltage is increased beyond its operation window to improve the energy density. Diamond is a durable and biocompatible electrode material for supercapacitors, while at the same time provides a larger voltage window in biological environments. For applications requiring higher energy density, diamond-based pseudocapacitors (PCs) have also been developed, which combine EDLCs with fast electrochemical reactions. Here we inspect the properties of diamond-related materials and discuss their advantages and disadvantages when used as EDLC and PC materials. We argue that further optimization of the diamond surface chemistry and morphology, guided by computational modelling of the interface, can lead to supercapacitors with enhanced performance. We envisage that such diamond-based supercapacitors could be used in a wide range of applications and in particular those requiring high performance in biomedical applications.

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Photoelectrochemical Modelling of Semiconducting Electrodes for Neural Interfacing

Chambers

Prawer

Ahnood

2023

J. Electrochem. Soc.

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Semiconducting electrodes are increasingly utilised for neural interfacing applications, such as neural recording, stimulation, and photomodulation. To characterise the performance of these electrodes, photoelectrochemical analysis is often undertaken in biologically relevant electrolytes. These include electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and for photomodulation applications, photocurrent (PC) measurements. From such measurements, it is possible to deduce key properties of semiconductor surfaces, such as electrochemical impedance and capacitance, as well as mechanisms of charge transfer. To extract these parameters from the experimental data, equivalent electrical circuit modelling is often employed, but usually only for a single technique at a time which often misses key insights about the processes occurring at the electrode-electrolyte interface. Here we present an equivalent circuit model that simultaneously describes the results from CV, EIS, and PC transient measurements. Using semiconducting nitrogen-doped ultrananocrystalline diamond (N-UNCD) electrodes in saline solution, we show that the model describes physical mechanisms that occur at the interface with electrolyte, encompassing the space charge region, the electrical double layer, and the electrolyte. Using the model we are able to optimise parameters relevant for neural interfacing and suggest that this framework may assist in the characterisation of other semiconducting electrodes.

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Towards optical neuromodulation using nitrogen-doped ultrananocrystalline diamond photoelectrodes

Cited by 4 publications

References 65 publications

Control of Neuronal Survival and Development Using Conductive Diamond

Control of Neuronal Survival and Development Using Conductive Diamond

Diamond Supercapacitors: Towards Durable, Safe, and Biocompatible Aqueous-Based Energy Storage

Photoelectrochemical Modelling of Semiconducting Electrodes for Neural Interfacing

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