Towards non-invasive assessment of cardiovascular physiology by combining cardiac MRI with predictive biomechanical modeling

Abstract

Biomechanical models coupled with cardiovascular MRI (CMR) have the potential to provide non-invasively physiological parameters of clinical interest. The approach is presented and validated on a group of 10 patients who underwent CMR and invasive catheterization. Patient-specific models are built based on CMR data and maximum/minimum arterial pressure. The stroke work, derived from ventricular pressure-volume (P-V) loops, was comparable between the measured and simulated P-V loops, suggesting the high quality of the in silico loops. An excellent correlation of the model-derived myocardial contractility with maximum time-derivative of ventricular pressure gives an opportunity for the non-invasive characterization of patients’ inotropic state.