Towards MRI T2 contrast agents of increased efficiency

Branca, Marlène; Marciello, Marzia; Ciuculescu-Pradines, Diana; Respaud, Marc; Morales, M.P.; Serra, R.; Casanove, Marie‐José; Amiens, Catherine

doi:10.1016/j.jmmm.2014.10.086

Cited by 27 publications

(12 citation statements)

References 19 publications

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“…Then the solution was exposed to air to generate a thin iron oxide shell. Formation of the oxide has been reported elsewhere [39,40]. Whether it consisted of maghemite, magnetite or a gradient of both was not investigated in this work but it is generally admitted that magnetite is the main component of the oxide shell close to the residual iron core while the interface with air and water mostly consists in maghemite [13,[41][42][43].…”

Section: Silica Coated Fe@feox Npsmentioning

confidence: 82%

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging

et al. 2019

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The growing concern over the toxicity of Gd-based contrast agents used in magnetic resonance imaging (MRI) motivates the search for less toxic and more effective alternatives. Among these alternatives, iron–iron oxide (Fe@FeOx) core-shell architectures have been long recognized as promising MRI contrast agents while limited information on their engineering is available. Here we report the synthesis of 10 nm large Fe@FeOx nanoparticles, their coating with a 11 nm thick layer of dense silica and functionalization by 5 kDa PEG chains to improve their biocompatibility. The nanomaterials obtained have been characterized by a set of complementary techniques such as infra-red and nuclear magnetic resonance spectroscopies, transmission electron microscopy, dynamic light scattering and zetametry, and magnetometry. They display hydrodynamic diameters in the 100 nm range, zetapotential values around −30 mV, and magnetization values higher than the reference contrast agent RESOVIST®. They display no cytotoxicity against 1BR3G and HCT116 cell lines and no hemolytic activity against human red blood cells. Their nuclear magnetic relaxation dispersion (NMRD) profiles are typical for nanomaterials of this size and magnetization. They display high r2 relaxivity values and low r1 leading to enhanced r2/r1 ratios in comparison with RESOVIST®. All these data make them promising contrast agents to detect early stage tumors.

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Section: Silica Coated Fe@feox Npsmentioning

confidence: 82%

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging

et al. 2019

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“…To overcome this shortcoming, one approach is to modify nanoparticles surface with various surface stabilizing agents that ensure their stability, biodegradability, non-toxicity as well as prolonging their circulation time in vivo. Although surface modification is successful in prolonging the SPIONs circulation time in vivo, according to the Koening – Kellar model, they could also influence the longitudinal (r 1 ) and transverse (r 2 ) relaxivities characteristics of SPIONs as a result of change in size, composition, accumulation situation in the biological environment, magnetization, hydrophilicity and surface properties [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of polymer coatings on magnetite nanoparticles performance as MRI contrast agents: a comparative study

et al. 2015

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BackgroundSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most commonly used negative MRI contrast agent which affect the transverse (T2) relaxation time. The aim of the present study was to investigate the impact of various polymeric coatings on the performance of magnetite nanoparticles as MRI contrast agents.MethodsFerrofluids based on magnetite (Fe3O4) nanoparticles (SPIONs) were synthesized via chemical co-precipitation method and coated with different biocompatible polymer coatings including mPEG-PCL, chitosan and dextran.ResultsThe bonding status of different polymers on the surface of the magnetite nanoparticles was confirmed by the Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA). The vibrating sample magnetometer (VSM) analysis confirmed the superparamagnetic behavior of all synthesized nanoparticles. The field–emission scanning electron microscopy (FE-SEM) indicated the formation of quasi-spherical nanostructures with the final average particle size of 12–55 nm depending on the type of polymer coating, and X-ray diffraction (XRD) determined inverse spinel structure of magnetite nanoparticles. The ferrofluids demonstrated sufficient colloidal stability in deionized water with the zeta potentials of −24.2, −16.9, +31.6 and −21 mV for the naked SPIONs, and for dextran, chitosan and mPEG-PCL coated SPIONs, respectively. Finally, the magnetic relaxivities of water based ferrofluids were measured on a 1.5T clinical MRI instrument. The r2/r1 value was calculated to be 17.21, 19.42 and 20.71 for the dextran, chitosan and mPEG-PCL coated SPIONs, respectively.ConclusionsThe findings demonstrated that the value of r2/r1 ratio of mPEG-PCL modified SPIONs is higher than that of some commercial contrast agents. Therefore, it can be considered as a promising candidate for T2 MRI contrast agent.

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“…In particular, they are widely employed in targeted drug delivery [1,2], catalysis [3], magnetic hyperthermia [4], magnetic data storage [5] and as contrast agents in MRI [6][7][8][9][10]. Thus, diverse synthetic routes to prepare iron-oxide nanoparticles have been developed.…”

Section: Introductionmentioning

confidence: 99%

Impact of heating mode in synthesis of monodisperse iron-oxide nanoparticles via oleate decomposition

et al. 2015

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Towards MRI T2 contrast agents of increased efficiency

Cited by 27 publications

References 19 publications

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging

Silica Coated Iron/Iron Oxide Nanoparticles as a Nano-Platform for T2 Weighted Magnetic Resonance Imaging

The impact of polymer coatings on magnetite nanoparticles performance as MRI contrast agents: a comparative study

Impact of heating mode in synthesis of monodisperse iron-oxide nanoparticles via oleate decomposition

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