Towards Modern-Age Advanced Sensors for the Management of Neurodegenerative Disorders: Current Status, Challenges and Prospects

Abstract

Neurodegenerative diseases (NDD) are progressive degenerative disorders of the neurological system with significant social impact worldwide. Their detection at the initial stage is necessary to provide proper therapeutic interventions. Biosensors have emerged as one of the next-generation tools for detecting and monitoring physiochemical changes associated with neurological disorders. This article discusses the current status and challenges of different state-of-the-art sensors which can detect NDD biomarkers. A brief overview of developing advanced biosensors with the help of nanotechnology integration, mainly polymer-based functional nanomaterials, has been mentioned as the prospect of these biosensors for NDD detection and management.

Review—Exploring Technological Innovations of Doped Rare Earth Materials

“…73,74 Therefore, both the evaluation and treatment of brain illnesses are seriously hampered by the complexities of the cerebral nerves and the restricted ability of brain tissues towards regeneration, and the difficulty of obtaining conventional medications well over the blood-brain barrier (BBB). 75 Neurodegenerative diseases (NDD) are significantly degenerative disorders of the neurological system with prominent social impact worldwide 76 Furthermore, the brain is sensitive and even slight illnesses or damage leads to significant problems. Consequently, the establishment of non-invasive, rapid, and effective visual diagnostic and treatment strategies is crucial for comprehending and addressing brain disorders.…”

“…Owing to their distinct electrical, optical and magnetic characteristics, REbased materials exhibit numerous advantages with future application opportunities in neuroimaging and the treatment of brain illnesses. [76][77][78] High magnetic moments, high X-ray absorption coefficients and comparatively long electron relaxation times are ECS Journal of Solid State Science and Technology, 2023 12 047006 characteristics of materials doped with Gd 3+ , Ho 3+ and Dy 3+ ions. Consequently, MRI and CT neuroimaging have remarkable spatial resolutions.…”

Automated Quantification of DNA Damage Using Deep Learning and Use of Synthetic Data Generated from Basic Geometric Shapes

“…It is critical to study the genotoxicity of novel substances in varied domains such as pharmaceuticals, environmental science and nanotechnology. [1][2][3] Nanoparticles, given their small size, can interact with the cellular DNA. This interaction can cause the strand breaks or modifications.…”

Exploring the Influence of Temperature and Time on the Formation and Properties of 3D Flower-Like MoS2 Nanostructures Synthesized via Hydrothermal Method

“…Two-dimensional (2D) transition metal dichalcogenides (TMDs) materials have gained immense research interests owing to their promising electrical, mechanical, optical and chemical properties. [1][2][3][4][5][6] These materials, including MoS 2 , WS 2 , MoSe 2 , VS 2, WSe 2 and many more, have shown great potentials for use in various applications, such as electronic devices, gas sensing devices, energy storage devices, hydrogen evolution reactions, solar cells, lubricants, etc. 2,[7][8][9][10][11][12][13][14] MoS 2 , as one of the representative members of TMDs, is a well-known two-dimensional (2D) material.…”