Towards Micropump- and Microneedle-based Drug Delivery using Micro Transdermal Interface Platforms (MicroTIPs)

Tjulkins, Fjodors; Sebastian, Ryan; Guillerm, Theo; Clover, A. James P.; Hu, Yuan; Lyness, Alexander; O’Mahony, Conor

doi:10.1109/embc48229.2022.9871455

Cited by 1 publication

(3 citation statements)

References 15 publications

(15 reference statements)

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“…Skin insertion tests were performed using a microneedle array and an impact inserter device. [ 34 ] Ex vivo human abdominal skin, discarded after cosmetic surgical procedures, was obtained following ethical approval by the Clinical Research Ethics Committee of the Cork Teaching Hospitals (CREC) and informed consent from all patients (approval reference ECM 4 (aa) 06/08/13). This was incubated in PBS before being clamped in a customized 3D‐printed jig for controlled stretching.…”

Section: Methodsmentioning

confidence: 99%

“…The CF–MN electrode was applied to the skin sample with an impact energy of ≈0.38 J cm −2 and 5 N residual force. [ 34,36 ]…”

Section: Methodsmentioning

confidence: 99%

“…Many microfabrication technologies used for microneedle manufacture have limitations due to their requirements for expensive equipment and complex infrastructure. [24][25][28][29][30][31][32][33][34][35][36][37][38][39][40] Micromoulding technology is a simpler and cost-effective alternative that enables the production of sharp and precise microneedles. We have previously demonstrated a double-sided micromoulding procedure for the production of sharp-tipped microneedle elec-trodes that also incorporated through-wafer vias to facilitate metallization at the wafer scale.…”

Section: Introductionmentioning

confidence: 99%

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Flexible, Conductive Fabric‐Backed, Microneedle Electrodes for Electrophysiological Monitoring

Singh,

Bocchino,

Guillerm

et al. 2023

Adv Materials Technologies

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Microneedle‐based electrodes have attracted significant attention due to their potential applications in high‐quality, long‐term electrophysiological monitoring. In this study, micromoulding technology is used to develop a flexible, conductive fabric microneedle (CF–MN) electrode by bonding a conductive textile to polymeric microneedle arrays. The resulting electrode conforms to the curved surfaces of the body, and the use of a conductive textile backing reduces metallization time and costs by 50% over double‐sided dry electrodes. The electrode‐skin impedance of the CF–MN electrodes is significantly lower than that of gel electrodes over a wide frequency range, and tests on healthy volunteers, both at rest and under a range of ambulatory conditions, showed that the electrodes are capable of acquiring electrocardiography (ECG) and electromyography (EMG) signals that have a comparable kurtosis and signal‐to‐noise ratio to those recorded using conventional electrodes, but without the need for skin preparation or the use of a wet gel. The biomechanical properties of the electrode are also characterized. This is the first demonstration of CF–MN electrodes that can ultimately be integrated into clothing, which in turn can facilitate personalized cardiac health management by enabling continuous, long‐term ECG/EMG monitoring during daily activities.

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Section: Methodsmentioning

confidence: 99%

“…The CF–MN electrode was applied to the skin sample with an impact energy of ≈0.38 J cm −2 and 5 N residual force. [ 34,36 ]…”

Section: Methodsmentioning

confidence: 99%