Towards low-cost bioanalytical tools for sarcosine assays for cancer diagnostics

Wang

et al. 2018

J. Electrochem. Soc.

Sarcosine is a newly discovered effective biomarker for prostate cancer. However, the low concentration of sarcosine in tissue cells, plasma or urine blocks the development of sarcosine biosensors. In this manuscript, porous zeolitic imidazolate framework-8 (ZIF8) was synthesized and was used as carriers to load nano platinum (Pt@ZIF8). The porous structure of ZIF8 helped to stabilize the nano platinum and keep its high catalytic activity. The Pt@ZIF8 modified sarcosine biosensor had good response toward sarcosine due to its unique structure and morphology. The linear range of the as prepared biosensor is from 5 to 30 μM, which is consistent with the detection demand. The prepared sarcosine biosensor is suitable to be developed as a kind of portable diagnostic facilities for prostate cancer. Prostate cancer (PCa) is one of the major diseases that influence the health and life expectancy of men over 50 years' old.

mentioning

confidence: 99%

Nano Pt@ZIF8 Modified Electrode and Its Application to Detect Sarcosine

Wang

et al. 2018

J. Electrochem. Soc.

“…Urine as a secretion fluid might also mirror the actual health conditions of an individual and metabolites typical for a particular disease might be found at increased levels in positive patients. Prostate cancer and urinary tract infection might be confirmed by CE‐C 4 D of increased levels of sarcosine ( N ‐methyl‐glycine) and by simultaneous CE‐C 4 D of creatinine and acetate in urine, respectively.…”

Section: Applications Of Ce‐c4dmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques: Developments from 2016 to 2018

Kubáň

Hauser

2018

Electrophoresis

The publications concerning capacitively coupled contactless conductivity detection for the 2-year period from mid-2016 to mid-2018 are covered in this update to the earlier reviews of the series. Relatively few reports on fundamental investigations or new designs have appeared in the literature in this time interval, but the development of new applications with the detection method has continued strongly. Most often, contactless conductivity measurements have been employed for the detection of inorganic or small organic ions in conventional capillary electrophoresis, less often in microchip electrophoresis. A number of other uses, such as detection in chromatography or the gauging of bubbles in streams have also been reported.

Biomedical Chromatography

“…A CE‐C 4 D method for determination of sarcosine in human urine was demonstrated (Mazzu‐Nascimento, Gomes Carneiro Leão, Catai, Morbioli, & Carrilho, ). Using a BGE consisting of 10 mmol L −1 of triethylamine the method was able to separate the sarcosine from 12 amino acids.…”

Section: Biomedical Analysismentioning

confidence: 99%

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Elbashir

Schmitz

Aboul‐Enein

2017

Capacitively coupled contactless conductivity detection (C D) has appeared as a powerful technique for the detection of compounds lacking chromogenic or fluorogenic group. Since our last review (Biomedical Chromatography 2014; 28: 1502-1506) several new capillary electrophoresis (CE)-C D methods have been reported. This review provides an update of the most recent utilization of CE-C D in the field of pharmaceutical, biomedical and food analysis covering the period from February 2014 to October 2016. The use of CE with C D in the pharmaceutical field has been shown in many papers. Examples illustrate the applicability of CE-C D in the fields of pharmaceutical, biomedical and food analysis. Finally, general conclusions and perspectives are provided.