Towards interbreed IBD fine mapping of the mh locus: Double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed

Dunner, S.; Charlier, Carole; Farnir, Frédéric; Brouwers, Benoît; Cañón, Javier; Georges, Michel

doi:10.1007/s003359900462

Cited by 47 publications

(26 citation statements)

References 11 publications

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“…Asturiana and Belgian Blue are known to carry the same variant at the GDF-8 locus, which is different from that found in Piedmontese (Dunner et al, 1997;McPherron and Lee, 1997;Grobet et al, 1998). The majority of the Belgian Blue and Asturiana samples were homozygous for an 11-bp deletion (mh) previously reported in these breeds (Belgian Blue: 96% mh/mh, 4% +/mh; Asturiana: 88% mh/mh, 10% +/mh, 2% +/+) (Dunner et al, 1997;Grobet et al, 1997). We did not know the frequency of the double-muscling mutation in the Piedmontese sample used, but the estimated frequency of double muscling for that population is close to 100%.…”

Section: Breed Samplesmentioning

confidence: 86%

Signatures of selection? Patterns of microsatellite diversity on a chromosome containing a selected locus

et al. 2003

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This paper explores patterns of genetic diversity near a locus known to have been under selection. The myostatin gene (GDF-8) has been shown to be associated with double muscling, a phenotype selected for in a number of cattle breeds. We examined population genetic parameters for microsatellite loci at varying distances from GDF-8 in doublemuscled (DM) and non-double-muscled (non-DM) cattle breeds in order to assess patterns of diversity. A theoretical analysis was also performed to predict the patterns of diversity expected under different scenarios. We found differences in the patterns of heterozygosity, allele diversity and linkage disequilibrium between DM and non-DM breeds. However, there were some exceptions to the predicted patterns. These are discussed in light of the histories of the breeds and the potential for using microsatellite diversity for mapping trait genes in livestock populations.

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Section: Breed Samplesmentioning

confidence: 86%

Signatures of selection? Patterns of microsatellite diversity on a chromosome containing a selected locus

et al. 2003

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“…As an important gene regulator of muscle growth and development, the MSTN gene has been well studied in livestock such as cattle (Dunner et al, 1997;Grobet et al, 1998;Casas et al, 1999) and pigs (Sonstegard et al, 1998;Li et al, 2002). However, the relationship between the MSTN gene variants and the meat produced as well as the meat quality in rabbits is rarely reported.…”

Section: Discussionmentioning

confidence: 99%

“…The only base mutation lies in the upstream regulatory region, implying that MSTN gene expression and regulation vary in different species of livestock. For example, the cattle MSTN gene is located on the 2nd autosomal (Dunner et al, 1997), and some studies have found that the cattle double-muscle trait is caused by mutations in this gene. An SNP (G→A conversion) in the MSTN gene exon 3 of Piedmont cattle causes the tyrosine to replace cysteine (Grobet et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Rabbit MSTN gene polymorphisms and genetic effect analysis

Qiao

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We analyzed meat samples of nine pure lines of rabbit and its 37 hybrid combinations by sequencing and singlestrand conformation polymorphism techniques to explore genetic polymorphisms of all the three exon regions and part of the 5'-regulatory region of the myostatin (MSTN) gene. Thus, we detected a single nucleotide mutation (T→C) on the 476 locus of the 5'-regulatory region, but no mutation sites were detected in the exon areas. The correlation analysis showed that the mutation had some favorable genetic effects, and it resulted in increased liver weight, carcass weight, forelegs weight, back and waist weight, ham weight, and tare weight, whereas it decreased muscle drip loss and cooking loss (P < 0.05). These results suggest that the mutations in the upstream regulatory region of the MSTN gene are beneficial to the rabbit soma development, and the mutations can be used as molecular markers for the selection of the meat quality of rabbits.

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“…Whereas LD has been extensively used in humans or mice, positional cloning experiments in domestic animals have seldom used this approach (Dunner et al 1997;Riquet et al 1999). This is rather paradoxical, as the population structure in domestic ruminants seems particularly adapted to LD analysis.…”

Section: Pis Linkage Disequilibrium Mappingmentioning

confidence: 94%

Fine Mapping Suggests that the Goat Polled Intersex Syndrome and the Human Blepharophimosis Ptosis Epicanthus Syndrome Map to a 100-kb Homologous Region

Schibler

Cribiu²,

Oustry-Vaiman³

et al. 2000

Genome Res.

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To clone the goat Polled Intersex Syndrome (PIS) gene(s), a chromosome walk was performed from six entry points at 1q43. This enabled 91 BACs to be recovered from a recently constructed goat BAC library. Six BAC contigs of goat chromosome 1q43 (ICC1–ICC6) were thus constructed covering altogether 4.5 Mb. A total of 37 microsatellite sequences were isolated from this 4.5-Mb region (16 in this study), of which 33 were genotyped and mapped. ICC3 (1500 kb) was shown by genetic analysis to encompass the PIS locus in a ∼400-kb interval without recombinants detected in the resource families (293 informative meioses). A strong linkage disequilibrium was detected among unrelated animals with the two central markers of the region, suggesting a probable location for PIS in ∼100 kb. High-resolution comparative mapping with human data shows that this DNA segment is the homolog of the human region associated withBlepharophimosis Ptosis Epicanthus inversus Syndrome(BPES) gene located in 3q23. This finding suggests that homologous gene(s) could be responsible for the pathologies observed in humans and goats.[The sequence data, PCR primers and PCR conditions for STS and microsatellites described in this paper have been submitted to the GenBank data library under accession nos.AQ666547–AQ666579, AQ686084–AQ686129, AQ793920–793931,AQ810429–AQ810527, G41201–G41228, and G54270–G54286.]

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Towards interbreed IBD fine mapping of the mh locus: Double-muscling in the Asturiana de los Valles breed involves the same locus as in the Belgian Blue cattle breed

Cited by 47 publications

References 11 publications

Signatures of selection? Patterns of microsatellite diversity on a chromosome containing a selected locus

Signatures of selection? Patterns of microsatellite diversity on a chromosome containing a selected locus

Rabbit MSTN gene polymorphisms and genetic effect analysis

Fine Mapping Suggests that the Goat Polled Intersex Syndrome and the Human Blepharophimosis Ptosis Epicanthus Syndrome Map to a 100-kb Homologous Region

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