2009 IEEE International Conference on Bioinformatics and Biomedicine 2009
DOI: 10.1109/bibm.2009.88
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Towards Identification of Human Disease Phenotype-Genotype Association via a Network-Module Based Method

Abstract: Inspired by recent discovery that human disease phenome shows a modular organization on the genetic landscape, we introduce a network-module based method towards phenotype-genotype association inference and disease gene identification. This approach integrates protein-protein interaction network, phenotype similarity network and known phenotype-genotype associations, and then decomposes the resulted assembled network into modules (or communities) wherein we identified and prioritized the disease genes from the… Show more

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