2020
DOI: 10.1136/bmjopen-2020-039234
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Towards HCV elimination among people who inject drugs in Hai Phong, Vietnam: study protocol for an effectiveness-implementation trial evaluating an integrated model of HCV care (DRIVE-C: DRug use & Infections in ViEtnam–hepatitis C)

Abstract: IntroductionIn Vietnam, people who inject drugs (PWID), who are the major population infected by hepatitis C virus (HCV), remain largely undiagnosed and unlinked to HCV prevention and care despite recommended universal hepatitis C treatment. The data on the outcomes of HCV treatment among PWID also remain limited in resource-limited settings. The DRug use & Infections in ViEtnam–hepatitis C (DRIVE-C) study examines the effectiveness of a model of hepatitis C screening and integrated care targeting PWID tha… Show more

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Cited by 15 publications
(13 citation statements)
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“…54 In Vietnam preventative interventions have been implemented since 2008, including opioid substitution therapy, universal antiretroviral treatment (ART) for HIV-infected PWID, and financing of community-based organisations to deliver harm reduction and distribute free syringes. 55 In 2015 the MOH expanded methadone treatment to at least 30 provinces to provide treatment for more than 80,000 drug users. 56 While these initiatives have been effective in reducing the incidence of HIV, incidence of HCV seroconversions in PWID remains very high 57 and we found no significant reduction in HCV antigen prevalence in the last decade.…”
Section: Discussionmentioning
confidence: 99%
“…54 In Vietnam preventative interventions have been implemented since 2008, including opioid substitution therapy, universal antiretroviral treatment (ART) for HIV-infected PWID, and financing of community-based organisations to deliver harm reduction and distribute free syringes. 55 In 2015 the MOH expanded methadone treatment to at least 30 provinces to provide treatment for more than 80,000 drug users. 56 While these initiatives have been effective in reducing the incidence of HIV, incidence of HCV seroconversions in PWID remains very high 57 and we found no significant reduction in HCV antigen prevalence in the last decade.…”
Section: Discussionmentioning
confidence: 99%
“…These additional costs need to be minimised through ensuring that test costs are kept low and linkage to care rates are high. [24,26,30]) and have sensitivity and specificity of 100% as they are the gold standard against which the RDTs are compared.…”
Section: Discussionmentioning
confidence: 99%
“…We set a before-after observational study among subjects drawn from the DRIVE-C survey, which aimed to implement a massive HCV test-and-treat approach to control the HCV epidemic among PWID in Haiphong, Vietnam. The full study protocol is published elsewhere [ 18 ]. All study participants signed an informed consent form that authorises the use of the banked samples for sub-studies related to the HIV and HCV epidemic among PWID.…”
Section: Methodsmentioning
confidence: 99%
“…More than half of them have been exposed to HCV, thereby making this population a non-negligible reservoir in terms of public health and HCV elimination. Moreover, HIV/HCV coinfections are very high among PWID living with HIV (PLHIV), from 72% to 91% [ 17 , 18 ]. This population is particularly exposed to several potent mitotoxic drugs, including those used in HIV treatments, which have been implicated in severe side effects such as myopathies, peripheral neuropathies, pancytopenia, or lipodystrophy, with mitochondrial dysfunction through off-target effects on mitochondrial polymerases as the underlying mechanism [ 19 ].…”
Section: Introductionmentioning
confidence: 99%