Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects

Shaffaf, Tina; Forouhi, Saghi; Ghafar-Zadeh, Ebrahim

doi:10.3390/mi12080915

Cited by 7 publications

(3 citation statements)

References 87 publications

(111 reference statements)

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“…Electrochemical biosensors have received enormous attention owing to their simplicity, affordability, and potential for miniaturization. These tiny devices utilize tailored electrodes that serve as receptors or transducers, depending on the specific requirements, to enable real-time, specific, and accurate target monitoring [ 95 , 96 , 97 ]. By extracting potentiometric or amperometric signals from the sensing electrode, information linked to the analyte presence can be obtained [ 98 , 99 , 100 ].…”

Section: Microfluidic-based Smart Diagnostic Platform For Covid-19 Di...mentioning

confidence: 99%

Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond

Yadav,

Verma,

Yadav

et al. 2023

Micromachines

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The pandemic of COVID-19 and its widespread transmission have made us realize the importance of early, quick diagnostic tests for facilitating effective cure and management. The primary obstacles encountered were accurately distinguishing COVID-19 from other illnesses including the flu, common cold, etc. While the polymerase chain reaction technique is a robust technique for the determination of SARS-CoV-2 in patients of COVID-19, there arises a high demand for affordable, quick, user-friendly, and precise point-of-care (POC) diagnostic in therapeutic settings. The necessity for available tests with rapid outcomes spurred the advancement of POC tests that are characterized by speed, automation, and high precision and accuracy. Paper-based POC devices have gained increasing interest in recent years because of rapid, low-cost detection without requiring external instruments. At present, microfluidic paper-based analysis devices have garnered public attention and accelerated the development of such POCT for efficient multistep assays. In the current review, our focus will be on the fabrication of detection modules for SARS-CoV-2. Here, we have included a discussion on various strategies for the detection of viral moieties. The compilation of these strategies would offer comprehensive insight into the detection of the causative agent preparedness for future pandemics. We also provide a descriptive outline for paper-based diagnostic platforms, involving the determination mechanisms, as well as a commercial kit for COVID-19 as well as their outlook.

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Section: Microfluidic-based Smart Diagnostic Platform For Covid-19 Di...mentioning

confidence: 99%

Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond

Yadav,

Verma,

Yadav

et al. 2023

Micromachines

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“…While electrochemical biosensors are tiny devices that are affordable and easy to shrink, they are particularly popular due to their simplicity and lower cost. In an electrochemical biosensor, real-time, specific, and accurate target monitoring generally relies on a tailored electrode, which acts as either the receptor or transducer depending on the need [106][107][108]. Potentiometric or amperometric signals, related to the presence of the analyte of interest, can be extracted from the sensing electrode's information [109][110][111].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Microfluidics-Based POCT for SARS-CoV-2 Diagnostics

et al. 2022

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A microfluidic chip is a tiny reactor that can confine and flow a specific amount of fluid into channels of tens to thousands of microns as needed and can precisely control fluid flow, pressure, temperature, etc. Point-of-care testing (POCT) requires small equipment, has short testing cycles, and controls the process, allowing single or multiple laboratory facilities to simultaneously analyze biological samples and diagnose infectious diseases. In general, rapid detection and stage assessment of viral epidemics are essential to overcome pandemic situations and diagnose promptly. Therefore, combining microfluidic devices with POCT improves detection efficiency and convenience for viral disease SARS-CoV-2. At the same time, the POCT of microfluidic chips increases user accessibility, improves accuracy and sensitivity, shortens detection time, etc., which are beneficial in detecting SARS-CoV-2. This review shares recent advances in POCT-based testing for COVID-19 and how it is better suited to help diagnose in response to the ongoing pandemic.

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“…In light of the global health and also economic burden of AMR, point-of-care (POC) diagnostic tests can make an important contribution to improved quality of antibiotic prescribing, as they allow identifying and targeting those patients who actually need antibiotics [ 1 , 2 ]. While the value of POC tests has long been known for respiratory diseases [ 3 , 4 , 5 ], their tremendous benefit from a clinical and public health perspective was confirmed in the COVID-19 pandemic (e.g., use of polymerase chain reaction (PCR) tests) [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing, Pricing and Funding Point-of-Care Diagnostic Tests for Community-Acquired Acute Respiratory Tract Infections–Overview of Policies Applied in 17 European Countries

Vogler

Windisch

2022

Antibiotics

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Point-of-care diagnostic tests for community-acquired acute respiratory tract infections (CA-ARTI) can support doctors by improving antibiotic prescribing. However, little is known about health technology assessment (HTA), pricing and funding policies for CA-ARTI diagnostics. Thus, this study investigated these policies for this group of devices applied in the outpatient setting in Europe. Experts from competent authority responded to a questionnaire in Q4/2020. Information is available for 17 countries. Studied countries do not base their pricing and funding decision for CA-ARTI diagnostics on an HTA. While a few countries impose price regulation for some publicly funded medical devices, the prices of CA-ARTI diagnostics are not directly regulated in any of the surveyed countries. Indirect price regulation through public procurement is applied in some countries. Reimbursement lists of medical devices eligible for public funding exist in several European countries, and in some countries these lists include CA-ARTI diagnostics. In a few countries, the public payer funds the health professional for performing the service of conducting the test. Given low levels of regulation and few incentives, the study findings suggest room for strengthening pricing and funding policies of CA-ARTI diagnostics to contribute to increased acceptance and use of these point-of-care tests.

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Towards Fully Integrated Portable Sensing Devices for COVID-19 and Future Global Hazards: Recent Advances, Challenges, and Prospects

Cited by 7 publications

References 87 publications

Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond

Point-of-Care Devices for Viral Detection: COVID-19 Pandemic and Beyond

Microfluidics-Based POCT for SARS-CoV-2 Diagnostics

Assessing, Pricing and Funding Point-of-Care Diagnostic Tests for Community-Acquired Acute Respiratory Tract Infections–Overview of Policies Applied in 17 European Countries

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