Towards flow-through/flow injection electronic tongue for the analysis of pharmaceuticals

Ciosek, Patrycja; Wesoły, Małgorzata; Zabadaj, Marcin; Lisiecka, Joanna; Sollohub, Krzysztof; Cal, Krzysztof; Wróblewski, Wojciech

doi:10.1016/j.snb.2014.07.042

Cited by 30 publications

(17 citation statements)

References 37 publications

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“…FIA-ET system comprised the same detector (i.e., modular flow cell with miniaturized ISEs of classical architecture connected with each other), two-position multi-channel valve, and sample injection device with a loop for precise dosing of the injected sample ( Figure 1C). In this case, the carrier solution is continuously pumped into the detector cell and the sample is periodically introduced into the carrier stream, forming response signals in the form of peaks [60]. The great advantage of FIA is a large reduction of sample volume needed for the analysis.…”

Section: Different Architectures Of Sensor Arraysmentioning

confidence: 99%

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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Electronic tongue systems equipped with cross-sensitive potentiometric sensors have been applied to pharmaceutical analysis, due to the possibility of various applications and developing new formulations. Many studies already proved the complementarity between the electronic tongue and classical analysis such as dissolution tests indicated by Pharmacopeias. However, as a new approach to study pharmaceuticals, electronic tongues lack strict testing protocols and specification limits; therefore, their results can be improperly interpreted and inconsistent with the reference studies. Therefore, all aspects of the development, measurement conditions, data analysis, and interpretation of electronic tongue results were discussed in this overview. The critical evaluation of the effectiveness and reliability of constructed devices may be helpful for a better understanding of electronic tongue systems development and for providing strict testing protocols.

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Section: Different Architectures Of Sensor Arraysmentioning

confidence: 99%

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Labanska

Ciosek-Skibińska

Wróblewski

2019

Sensors

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“…The fluid system was composed of: a two position ten port Cheminert ® valve (Vici, USA), a sample loop (200 ul), a peristaltic pump (Minipuls 3, Gilson, France) used to fill the sample loop, and a syringe pump (KDS Model 200 Series, Holliston, USA) used to introduce the carrier solution into the flow-through sensor array. All elements were connected together using low-pressure connectors; additionally, air bubble catcher to remove air from carrier solution was applied [31]. Sensor qualification, sensor check, signal stabilization were applied in the form of the same procedure as in the case of Warsaw e-tongue for batch measurements.…”

Section: 34mentioning

confidence: 99%

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Pein

Kirsanov

Ciosek

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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a b s t r a c tElectronic tongue technology based on arrays of cross-sensitive chemical sensors and chemometric data processing has attracted a lot of researchers' attention through the last years. Several so far reported applications dealing with pharmaceutical related tasks employed different e-tongue systems to address different objectives. In this situation, it is hard to judge on the benefits and drawbacks of particular e-tongue implementations for R&D in pharmaceutics. The objective of this study was to compare the performance of six different e-tongues applied to the same set of pharmaceutical samples. For this purpose, two commercially available systems (from Insent and AlphaMOS) and four laboratory prototype systems (two potentiometric systems from Warsaw operating in flow and static modes, one potentiometric system from St. Petersburg, one voltammetric system from Barcelona) were employed. The sample set addressed in the study comprised nine different formulations based on caffeine citrate, lactose monohydrate, maltodextrine, saccharin sodium and citric acid in various combinations. To provide for the fair and unbiased comparison, samples were evaluated under blind conditions and data processing from all the systems was performed in a uniform way. Different mathematical methods were applied to judge on similarity of the e-tongues response from the samples. These were principal component analysis (PCA), RV matrix correlation coefficients and Tuckerís congruency coefficients.

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“…Such a device was utilized previously for the studies of different samples: discrimination between various formulations based on caffeine citrate (19), microencapsulated ibuprofen and roxithromycin (20,21,32) and for the analysis of acetaminophen, ascorbic acid and acetylsalicylic acid in a mixture (33). Final chemical images for appropriate time points were presented on 2D-PCA plots (Figs.…”

Section: Taste Masking Evaluation Of Microparticles Obtained With Cetmentioning

confidence: 99%

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

et al. 2017

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Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.Keywords: taste masking, electronic tongue, cetirizine dihydrochloride, microparticles, methacrylate copolymer, spray drying Unacceptable taste is an important problem encountered in the designing of new dosage forms. Taste masking of drug substances has been continuously changing with emerging techniques and new excipients (1-7). Taste masking can be carried out by various methods, depending on the therapeutic agent and dosage form. One of the simplest taste masking methods is addition of flavors, sweeteners and effervescent agents, but it is not always effective. In recent years, methods creating a physical barrier between active ingredients and taste buds have been developed for taste masking. One of them is spray drying, a relatively simple and convenient technology for the preparation of microparticles (8)(9)(10)(11)

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Towards flow-through/flow injection electronic tongue for the analysis of pharmaceuticals

Cited by 30 publications

References 37 publications

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Critical Evaluation of Laboratory Potentiometric Electronic Tongues for Pharmaceutical Analysis—An Overview

Independent comparison study of six different electronic tongues applied for pharmaceutical analysis

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

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