Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt

Abou-El-Naga, Iman F.

doi:10.1016/j.actatropica.2018.02.005

Cited by 30 publications

(20 citation statements)

References 78 publications

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“…Schistosomiasis control programs depend mainly on PZQ as a corner stone through mass drug administration. Although this strategy has had a great impact on curtailing transmission in different countries, the reliance on a single drug for any disease of this magnitude may lead to the development of drug resistant parasites (Abou-El-Naga, 2018). A recent proteomic study revealed that Hsp70 is associated with decreased sensitivity of adult S. mansoni to PZQ (Abou-El-Naga et al ., 2019).…”

Section: Different Stress Conditions In Schistosoma Mansoni Life Cyclementioning

confidence: 99%

“…PZQ is the current drug of choice and the only drug that is approved by the World Health Organization for the treatment of all species of Schistosoma (WHO, 1993; Cioli and Pica-Mattoccia, 2003). It has been used successfully in large-scale schistosomiasis control programs in many multiplicity of countries (Abou-El-Naga, 2018), therefore, the possible emergence of resistance might therefore is considered likely. There are several parasite isolates in the field and lab have shown reduced susceptibility to PZQ (Ismail et al ., 1994; Couto et al ., 2011; Abou-El-Naga et al ., 2019), these possibly being an indication for the emergence of more widespread drug resistance.…”

Section: Decreased Sensitivity Of Adult S Mansoni To Pzqmentioning

confidence: 99%

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Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel

Abou-El-Naga¹

2020

Parasitology

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Schistosoma mansoni is the most common species causing schistosomiasis. It has a complex life cycle involving a vertebrate definitive host and a snail intermediate host of the genus Biomphalaria. Each stage encounters a plethora of environmental stresses specially heat stress. Another sort of stress arises from repeated exposure of the parasite to praziquantel (PZQ), the only drug used for treatment, which leads to the development of resistance in the fields and the labs. Heat shock protein 70 (Hsp70) is found in different developmental stages of S. mansoni. It is immunogenic and regulate cercarial invasion besides its chaperone function. In the Biomphalaria/S. mansoni interaction, epigenetic modulations of the Hsp70 gene underscore the susceptibility phenotype of the snail. Hsp70 is up-regulated in adult S. mansoni with decreased sensitivity to PZQ. This could be due to the induction of oxidative and endoplasmic reticulum stress, induction of apoptosis, exposure to the stressful drug pressure and increase influx of calcium ions. Up-regulation of Hsp70 might help the worm to survive the schistosomicidal effect of the drug mainly by dealing with misfolded proteins, inhibition of apoptosis, induction of autophagy, up-regulation of the P-glycoprotein transporter and attenuation of the signalling from G protein coupled receptors.

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Section: Different Stress Conditions In Schistosoma Mansoni Life Cyclementioning

confidence: 99%

Section: Decreased Sensitivity Of Adult S Mansoni To Pzqmentioning

confidence: 99%

Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel

Abou-El-Naga¹

2020

Parasitology

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“…Since the implementation of different control strategies in 1922, schistosomiasis (S. mansoni) prevalence had substantially decreased to 0.2% in 2016 in most of the endemic areas. The first step from this 2016 control stage to elimination included the re-mapping of residual distribution of schistosomiasis in all endemic governorates using both the KK technique and a urine circulating cathodic antigen (CCA) test [26]. So far, 35 districts of 5 governorates have been re-mapped, while the survey of other governorates is still ongoing.…”

Section: Monitoring and Surveillance For Schistosoma Mansoni In Egyptmentioning

confidence: 99%

Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review

Saelens

Gabriël

2020

Pathogens

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An increasing global focus on neglected tropical diseases (NTDs) has resulted in the set up of numerous control and elimination activities worldwide. This is partly true for Taenia solium taeniasis/cysticercosis, the most important foodborne parasitic infection. Despite substantial progress, adequate monitoring and surveillance (M&S) are required to sustain a status of control/elimination. This is often lacking, especially for T. solium. Therefore, the objective was to conduct a systematic literature review of the currently available M&S systems at the control/elimination stage of the four top-ranked helminth NTDs. Specifically, Taenia spp., Echinococcus spp., Schistosoma spp., and soil-transmitted helminths (STHs) were considered to determine if there are any similarities between their M&S systems and whether certain approaches can be adopted from each other. The systematic review demonstrated that rigorous M&S systems have been designed for the control/elimination stage of both STHs and schistosomiasis, particularly in China. On the other hand, a concept of M&S for Taenia spp. and Echinococcus spp. has not been fully developed yet, due to a lack of epidemiological data and the fact that many endemic countries are far away from reaching control/elimination. Moreover, accurate diagnostic tools for all four diseases are still imperfect, which complicates proper M&S. Finally, there is an urgent need to develop and harmonize/standardize M&S activities in order to reliably determine and compare the epidemiological situation worldwide.

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“…Schistosomiasis represents a global health concern with over 700 million people at risk of contracting this disease (Weber et al, 2019). In Egypt eradicating this disease is a top governmental priority (Abou-El-Naga, 2018). Generally, chemotherapy is still one of the most effective methods for controlling Schistosoma infection (Bertão et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

et al. 2020

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SummaryBiomphalaria alexandrina snails have received much attention due to their great medical importance as vectors for transmitting Schistosoma mansoni infection to humans. The main objective of the present work was to assess the efficacy of miltefosin a synthetic molluscicidal drug and artemether a natural molluscicidal drug. The correlation between immunological and histological observations from light and electron microscopy of the hemocytes of B. alexandrina post treatment with both drugs was also evaluated. LC50 and LC90 values were represented by 13.80 ppm and 24.40 ppm for miltefosine and 16.88 ppm and 27.97 ppm for artemether, respectively. The results showed that the treatment of S. mansoni-infected snails and normal snails with sublethal dose of miltefosine (LC25=8.20 ppm) and artemether (LC25=11.04 ppm) induced morphological abnormalities and a significant reduction in hemocytes count.

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Towards elimination of schistosomiasis after 5000 years of endemicity in Egypt

Cited by 30 publications

References 78 publications

Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel

Heat shock protein 70 (Hsp70) in Schistosoma mansoni and its role in decreased adult worm sensitivity to praziquantel

Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review

Efficacy of Miltefosine and Artemether on infected Biomphalaria alexandrina snails with Schistosoma mansoni: immunological and histological studies

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