Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles

Bucharskaya, Alla B.; Maslyakova, Galina N.; Terentyuk, Georgy S.; Yakunin, A. N.; Avetisyan, Yuri A.; Bibikova, Olga; Tuchina, Elena S.; Khlebtsov, Boris N.; Khlebtsov, Nikolai G.; Tuchin, Valery V.

doi:10.3390/ijms17081295

Cited by 119 publications

(65 citation statements)

References 128 publications

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“…Nevertheless, the AuNPs cannot inhibit SW620 cell viability as previously reported. 45 Although AuNPs alone have been shown to exert no impact on tumor growth in various studies, especially in photothermal therapy field; 46 however, different sizes of AuNPs show different effects in VEGF165-induced proliferation of HUVECs, the specific inhibitory effects of AuNPs size are better in 10-20 nm (diameter). 47 In our study, the nanosphere of AuNPs and the size of AuNPs used was 15 nm in our experiment, which was an effective size to inhibit the VEGF165-induced activation.…”

Section: Discussionmentioning

confidence: 99%

Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels

Zhao¹,

Pan²,

Li³

et al. 2018

IJN

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BackgroundTumor vessels were persistently compressed by solid stress from tumor interstitial matrix, resulting in limited vessel perfusion and oxygen concentrations. Collagen within matrix participated in transmitting the solid stress to tumor vessels and limiting drug delivery.PurposeThe objective of this study was to identify whether gold nanoparticles (AuNPs) were able to decompress colorectal cancer vessels and enhance vessel perfusion as well as drug delivery in colorectal cancer.MethodsColorectal cancer xenograft mice were treated with AuNPs or normal saline for 14 days. The cancer stromal collagen I level, cancer vessel perfusion, hypoxia of tumor were tested by histological examination. We also test the solid stress in the two groups. Furtherly, the effect and the drug delivery of combined using AuNPs and cisplatin were tested. The effect and the underlying mechanism of AuNPs on SW620 cells were tested by CCK8, flow cytometry, Western-blot and atomic force microscope.ResultsAuNPs were able to decrease the density of colorectal cancer associated fibroblasts (CAFs), to reduce the production of tumor stromal collagen I, and to diminish the expression of profibrotic signals, including CTGF, TGF-β1 as well as VEGF in vivo and vitro via Akt signaling pathway. Consequently, AuNPs could alleviate solid stress in tumors, subsequently leading to enhanced vessel perfusion. Therefore, cisplatin as well as oxygen delivery to tumors were improved by AuNPs, which reduced hypoxia while sensitizing therapy of cisplatin in colorectal cancer model.ConclusionAuNPs were effective agents in enhancing cisplatin delivery and potentiating inhibiting tumor growth by decompressing colorectal cancer vessels.

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Section: Discussionmentioning

confidence: 99%

Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels

Zhao¹,

Pan²,

Li³

et al. 2018

IJN

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“…Such novel nanotechnologies may find future use in photothermal/photodynamic therapy to enhance the efficacy of bacteria elimination. [ 231,232 ]…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

476

368

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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“…Many research groups have already demonstrated the advantageous plasmonic photothermal effect of gold nanorods for various applications. 13,21,[24][25][26][27][28] The microscopic study presented here allows to additionally investigate the mechanism of this effect and the subsequently induced cell death as well as the influence of the targeted delivery system mediated by the IL-6 receptor. In our experiments, we find that for the targeted delivery system, the time until cell death during PPTT is significantly shorter than for non-targeted delivery.…”

Section: Introductionmentioning

confidence: 99%

Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods

et al. 2019

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Towards Effective Photothermal/Photodynamic Treatment Using Plasmonic Gold Nanoparticles

Cited by 119 publications

References 128 publications

Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels

Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Monitoring the death of single BaF3 cells under plasmonic photothermal heating induced by ultrasmall gold nanorods

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