Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybrids

Design, synthetic approach,in silicomolecular docking and antibacterial activity of quinazolin-2,4-dione hybrids bearing bioactive scaffolds

“…They were cultivated in Mueller Hinton broth at 35 ± 2 °C for 24 h. The antimicrobial activity and MIC were performed as reported by Qader et al (2021). 2,27–36…”

“…To gain insight into molecular interactions and docking scores, the molecular docking study 36,42,43 was carried out between the newly ligand molecules and the target enzyme. Herein, S. aureus tyrosyl-tRNA synthetase is a well-recognized attractive therapeutic target for antibacterial drug design.…”

Mini Review on The Synthesis and Biological Impact of Thiazoles

“…Rashdan et al, [5] have designed and synthesized a group of thiazole based drug like candidates. The structure of the newly developed molecules has demonstrated on bases of correct spectral and microanalytical data.…”

“…[61][62][63] The color variations occur by changing the PUT concentration as shown in (Figure 12b). [5] Figure 11. (a) (3D), and (b) (2D) representations of the binding interactions of the docked compounds 59 against TMPRSS2 (PDB ID : 1z8 g).…”

“…[1][2][3] It was reported that thiazoles and their based molecules revealed promising wide spectrum of biological and pharmaceutical applications. [4][5]14], [6][7][8][9][10][11][12][13] Hantzsch and Weber had described thiazoles for the first time in 1887. [15] Thiazoles exhibited physical and chemical properties similar to pyrimidines and pyridines, although thiazole derivatives sometimes behave like furan and thiophene.…”