Towards controlled drug delivery in brain tumors with microbubble-enhanced focused ultrasound

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

“…The latest research by Meng et al reported that the optimized NPs with virus-mimic surface topology combined with low-frequency ultrasound microbubbles significantly enhanced the permeability of the biological barrier and enhanced the distribution of NPs in solid tumors ( Meng et al, 2021 ). In recent years, the combination of NDDS and ultrasound microbubbles has shown great potential in improving gene transfection efficiency in gene therapy ( Tay and Xu, 2017 ; Wang et al, 2022a ; Kida et al, 2022 ), and improving the efficacy of chemotherapy drugs on a variety of tumors including PC ( Gao et al, 2019 ; Lee et al, 2020 ; Liu et al, 2020 ; Yang et al, 2022a ; Ngamcherdtrakul et al, 2022 ; Schoen et al, 2022 ). However, it should be noted that the size and concentration of microbubbles and the total amount of gas contained in the liquid are important factors affecting NDDS mediated by ultrasound microbubbles ( Kida et al, 2022 ).…”

Synergistic therapy for orthotopic gliomas via biomimetic nanosonosensitizer-mediated sonodynamic therapy and ferroptosis

“…1,2 The combination of focused ultrasound (US) and microbubbles (MBs) can reversibly open the BBB in a noninvasive manner with high spatial and temporal specificity, providing a promising method for the delivery of nanodrugs to the brain. [3][4][5] Recent studies have shown encouraging results of US-MBs in neurological diseases such as gliomas, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. [6][7][8][9][10][11] Moreover, US can induce sonodynamic therapy (SDT), which is an emerging anti-cancer approach, involving the USmediated activation of sonosensitizers and the generation of reactive oxygen species (ROS) that selectively kill tumor cells.…”

“…1,2 The combination of focused ultrasound (US) and microbubbles (MBs) can reversibly open the BBB in a noninvasive manner with high spatial and temporal specificity, providing a promising method for the delivery of nano-drugs to the brain. 3–5 Recent studies have shown encouraging results of US-MBs in neurological diseases such as gliomas, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. 6–11…”

A 3D printable perfused hydrogel vascular model to assay ultrasound-induced permeability

“…This process of using sonoporation utilizing the cavitation of microbubbles to enhance drug delivery is currently under intensive preclinical and clinical research for anticancer therapies to improve targeted drug delivery to a localized tumor, as well as to facilitate drug delivery across highly restrictive barriers such as the blood–brain barrier for brain diseases. 26,43–52…”

“…This process of using sonoporation utilizing the cavitation of microbubbles to enhance drug delivery is currently under intensive preclinical and clinical research for anticancer therapies to improve targeted drug delivery to a localized tumor, as well as to facilitate drug delivery across highly restrictive barriers such as the blood-brain barrier for brain diseases. 26,[43][44][45][46][47][48][49][50][51][52] This paper examines leveraging this 3D model to further understand sonoporation-assisted transport across an endothelial barrier in a dynamic, perfusable in vitro system. To do this, an improved endothelialization strategy was used via tuning media composition to achieve an endothelium displaying barrier function and responsiveness to external cues.…”