Towards continuous-to-continuous 3D imaging in the real world

Caucci, Luca; Liu, Z; Jha, Abhinav K.; Han, Haiyong; Furenlid, Lars R.; Barrett, Harrison H.

doi:10.1088/1361-6560/ab3fb5

Cited by 10 publications

(8 citation statements)

References 45 publications

(54 reference statements)

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“…More recently, we observed that SPECT LM emission data containing the energy attribute contains information to jointly estimate the activity and attenuation distributions [13]. Also, several studies have shown that LM data can yield improved reconstruction and quantification compared to binned data in SPECT imaging [14,15,16,17,18,19]. These investigations motivate the use of SPECT LM data containing the energy attribute for ASC.…”

Section: Introductionmentioning

confidence: 79%

A list-mode OSEM-based attenuation and scatter compensation method for SPECT

Rahman¹,

Laforest²,

Jha³

2020

Preprint

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Reliable attenuation and scatter compensation (ASC) is a prerequisite for quantification and beneficial for visual interpretation tasks in SPECT. In this paper, we develop a reconstruction method that uses the entire SPECT emission data, i.e. data in both the photopeak and scatter windows, acquired in list-mode format and including the energy attribute of the detected photon, to perform ASC. We implemented a GPUbased version of this method using an ordered subsets expectation maximization (OSEM) algorithm. The method was objectively evaluated using realistic simulation studies on the task of estimating uptake in the striatal regions of the brain in a 2-D dopamine transporter (DaT)-scan SPECT study. We observed that inclusion of data from the scatter window and using list-mode data yielded improved quantification compared to using data only from the photopeak window or using binned data. These results motivate further development of list-mode-based ASC methods that include scatter-window data for SPECT.

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Section: Introductionmentioning

confidence: 79%

A list-mode OSEM-based attenuation and scatter compensation method for SPECT

Rahman¹,

Laforest²,

Jha³

2020

Preprint

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“…The results from this study also motivate the development of methods to jointly estimate activity and attenuation distribution using only the SPECT emission data, especially if the computational requirements of processing LM data can be reduced. Efforts in the direction of reducing these computational requirements are currently underway [51,52].…”

Section: Discussionmentioning

confidence: 99%

Fisher information analysis of list-mode SPECT emission data for joint estimation of activity and attenuation distribution

et al. 2020

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Inverse Problems 36 (2020) 084002 M A Rahman et al a clinical system using realistic computational studies with 2D digital synthetic and anthropomorphic phantoms. Experiments with anthropomorphic phantoms simulated myocardial perfusion and dopamine transporter (DaT)-Scan SPECT studies. The method was also applied to LM data containing up to secondorder scatter for a synthetic phantom. The results show that the CRB obtained for the attenuation and activity coefficients was typically much lower than the true value of these coefficients. An increase in the number of detected photons yielded lower CRB for both the attenuation and activity coefficients. Further, we observed that systems with better energy resolution yielded a lower CRB for the attenuation coefficient. Overall, the results provide evidence that LM SPECT emission data, including the scatter-window data, contains information to jointly estimate the activity and attenuation coefficients.

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“…For some recent results, see Caucci. 32 A long review article on radiation dose and risk for imaging with ionizing radiation 27 provides a general review of methods of computing image-quality metrics as a function of radiation dose. This paper also develops several new graphical methods for depicting the tradeoffs among radiation dose, image quality and patient risk.…”

Section: Photon Counting and Photon Processingmentioning

confidence: 99%