Towards child versus adult brain mechanical properties

Chatelin, Simon; Vappou, Jonathan; Roth, Sébastien; Raul, Jean‐Sébastien; Willinger, Rémy

doi:10.1016/j.jmbbm.2011.09.013

Cited by 75 publications

(64 citation statements)

References 24 publications

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“…This range of moduli is very similar to ex vivo infant brain material properties published by others at shear strains of 0.5% to 50% and shear strain rates of 0.1s −1 to 8.33s −1 . (Chatelin et al 2012; Prange and Margulies 2002; Thibault and Margulies 1998) These studies demonstrated that shear testing across a range of strain magnitudes at constant strain rate produced little change in the infant shear modulus, suggesting that the infant shear modulus is insensitive to shear strain magnitude. (Prange and Margulies 2002; Thibault and Margulies 1998) Our study goes a step further to reveal that initial shear modulus values at high strain rates are very similar to those measured during ex vivo testing at substantially lower rates, demonstrating that the infant shear modulus is also relatively insensitive to strain rate.…”

Section: Discussionmentioning

confidence: 93%

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

Sullivan

Eucker

Gabrieli

et al. 2014

Biomech Model Mechanobiol

142

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A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer the range of optimal shear moduli for infant (5-day-old, 553-658 Pa) and 4-week old toddler piglet brain, (692-811 Pa) from comparisons with measured in situ tissue strains. The more mature brain modulus was found to have significant strain and strain rate dependencies not observed with the infant brain. Age-appropriate FEMs were then used to simulate experimental TBI in infant (n=36) and pre-adolescent (n=17) piglets undergoing a range of rotational head loads. The experimental animals were evaluated for the presence of clinically significant traumatic axonal injury (TAI), which was then correlated with FEM-calculated measures of overall and white matter tract-oriented tissue deformations, and used to identify the metric with the highest sensitivity and specificity for detecting TAI. The best predictors of TAI were the tract-oriented strain (6–7%), strain rate (38–40 s−1), and strain times strain rate (1.3–1.8 s−1) values exceeded by 90% of the brain. These tract-oriented strain and strain rate thresholds for TAI were comparable to those found in isolated axonal stretch studies. Furthermore, we proposed that the higher degree of agreement between tissue distortion aligned with white matter tracts and TAI may be the underlying mechanism responsible for more severe TAI after horizontal and sagittal head rotations in our porcine model of nonimpact TAI than coronal plane rotations.

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Section: Discussionmentioning

confidence: 93%

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

Sullivan

Eucker

Gabrieli

et al. 2014

Biomech Model Mechanobiol

142

View full text Add to dashboard Cite

show abstract

“…Several researchers used small surrogate animal brain to conduct tests [36][37][38][39][40]. It is also worth to mention that Chatelin et al [41] conducted oscillatory shear experiments using limited number of pediatric human brain samples at four age groups to investigate the effects of age and region on viscoelastic properties of human brain tissues. Although the aforementioned efforts have been made, age effects cannot be well established in the pediatric skull and brain due to limited number of sample size and large variations among those studies.…”

Section: Discussionmentioning

confidence: 99%

Prediction of skull fracture risk for children 0–9 months old through validated parametric finite element model and cadaver test reconstruction

Liu²,

Zhang

et al. 2015

Int J Legal Med

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Skull fracture is one of the most common pediatric traumas. However, injury assessment tools for predicting pediatric skull fracture risk is not well established mainly due to the lack of cadaver tests. Weber conducted 50 pediatric cadaver drop tests for forensic research on child abuse in the mid-1980s (Experimental studies of skull fractures in infants, Z Rechtsmed. 92: 87-94, 1984; Biomechanical fragility of the infant skull, Z Rechtsmed. 94: 93-101, 1985). To our knowledge, these studies contained the largest sample size among pediatric cadaver tests in the literature. However, the lack of injury measurements limited their direct application in investigating pediatric skull fracture risks. In this study, 50 pediatric cadaver tests from Weber's studies were reconstructed using a parametric pediatric head finite element (FE) model which were morphed into subjects with ages, head sizes/shapes, and skull thickness values that reported in the tests. The skull fracture risk curves for infants from 0 to 9 months old were developed based on the model-predicted head injury measures through logistic regression analysis. It was found that the model-predicted stress responses in the skull (maximal von Mises stress, maximal shear stress, and maximal first principal stress) were better predictors than global kinematic-based injury measures (peak head acceleration and head injury criterion (HIC)) in predicting pediatric skull fracture. This study demonstrated the feasibility of using age- and size/shape-appropriate head FE models to predict pediatric head injuries. Such models can account for the morphological variations among the subjects, which cannot be considered by a single FE human model.

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“…There have been several experimental studies of human brain tissue (Chatelin et al, 2012;Donnelly and Medige, 1997;Fallenstein et al, 1969;Franceschini et al, 2006;Kruse et al, 2008;Nicolle et al, 2004;Prange and Margulies, 2002;Prange et al, 2000;Sack et al, 2008Sack et al, , 2009Schiavone et al, 2009). However, with the exception of a few of these aforementioned studies (Franceschini et al, 2006;Prange and Margulies, 2002;Prange et al, 2000), each reported single-mode experiments, with tests in just tension, compression, or shear.…”

Section: Introductionmentioning

confidence: 99%

Fitted hyperelastic parameters for Human brain tissue from reported tension, compression, and shear tests

Morán

Smith

García

2014

Journal of Biomechanics

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Towards child versus adult brain mechanical properties

Cited by 75 publications

References 24 publications

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities

Prediction of skull fracture risk for children 0–9 months old through validated parametric finite element model and cadaver test reconstruction

Fitted hyperelastic parameters for Human brain tissue from reported tension, compression, and shear tests

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