Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement

Warriner, Claire L.; Fageiry, Samaher; Carmona, Lina Marcela; Miri, Andrew

doi:10.1016/j.neuroscience.2020.07.054

Cited by 7 publications

(6 citation statements)

References 119 publications

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“…and appear to reflect a set of motor primitives related to the control of song duration and the rate of note production. Future work will determine whether these spiking profiles map onto specific neuronal cell types in the OMC defined by critical circuit features, such as their output targets, as seen in motor cortical circuits in the laboratory mouse [40][41][42]. These results provide a striking example of how motor cortical dynamics can modulate song production, perhaps reflecting a voluntary mechanism of generating adaptive vocal flexibility.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neural dynamics in the rodent motor cortex enables flexible control of vocal timing

Banerjee

Chen

Druckmann

et al. 2023

Preprint

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Neocortical activity is thought to mediate voluntary control over vocal production, but the underlying neural mechanisms remain unclear. In a highly vocal rodent, the Alstons singing mouse, we investigate neural dynamics in the orofacial motor cortex (OMC), a structure critical for vocal behavior. We first describe neural activity that is modulated by component notes (~ 100 ms), likely representing sensory feedback. At longer timescales, however, OMC neurons exhibit diverse and often persistent premotor firing patterns that stretch or compress with song duration (~ 10 s). Using computational modeling, we demonstrate that such temporal scaling, acting via downstream motor production circuits, can enable vocal flexibility. These results provide a framework for studying hierarchical control circuits, a common design principle across many natural and artificial systems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neural dynamics in the rodent motor cortex enables flexible control of vocal timing

Banerjee

Chen

Druckmann

et al. 2023

Preprint

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“…Lesion 59,60 , anatomical [61][62][63] , and physiological 64 studies have focused on the role of primary (M1) and secondary (M2) motor cortices in control of relatively isolated and well-trained forelimb movements (e.g. reach and grasp) in primates 61,65 and rodents 66 . These studies have revealed correlations of cortical neuron activity with a range of movement parameters (e.g.…”

Section: Discussionmentioning

confidence: 99%

A cortical circuit for orchestrating oromanual food manipulation

Matho

et al. 2022

Preprint

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Cooperative forelimb and mouth movements during eating contribute to diet selection among vertebrates including the oromanual manipulatory skills in rodents and primates. Whereas spinal and brainstem circuits implement forelimb and orofacial actions, whether there is a specialized cortical circuit that flexibly assembles these to achieve cross-body and oromanual coordination for skilled manipulation remains unclear. Here we discover a cortical region and its cell-type-specific circuitry that orchestrates body postures and oromanual coordination for food manipulation in mice. An optogenetic screen of cortical areas and projection neuron types identified a rostral forelimb-orofacial area (RFO), wherein activation of pyramidal tract (PTFezf2) and intratelencephalic (ITPlxnD1) neurons induced concurrent posture, forelimb and orofacial eating-like movements. In a pasta-eating behavior, RFO PTFezf2and ITPlxnD1activity were closely correlated with picking up the pasta, adopting a sitting posture, oromanual manipulation, and hand-assisted biting. RFO inactivation and inhibition of RFO PTsFezf2and ITsPlxnD1impaired posture and oromanual coordination, leading to deficient pasta manipulation and biting. RFO is reciprocally connected to forelimb and orofacial sensorimotor areas as well as insular and visceral areas. Within this network, ITsPlxnD1project bilaterally to the entire network and the ventrolateral striatum and PTsFezf2project to multiple subcortical areas associated with forelimb and orofacial control. These results suggest that ITsPlxnD1select and coordinate the feeding program involving multiple body parts and PTsFezf2implement the fine details of movements. Our study reveals a neural circuit basis of hand-mouth coordination for object manipulation.

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“…1e), so sensory information must be used in real time to steer right limb movement. Thus, mice do not rely solely on a stereotyped movement strategy, performing adaptive forelimb movements expected to involve motor cortical influence 41 . Water-restricted mice climb intermittently in bouts throughout hour-long daily sessions, earning water rewards when they stop climbing based on the distance of the previous bout.…”

Section: An Ethological Movement Paradigmmentioning

confidence: 99%

Selective direct motor cortical influence during naturalistic climbing

Koh,

Ma,

Sarup

et al. 2023

Preprint

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Among the patterns of motor cortical activity, those that directly drive muscles remain unresolved. Lesion studies have led to the hypothesis that motor cortex functions primarily to improve movement efficacy by enabling patterns of muscle activity that the rest of the motor system cannot achieve. Yet such studies weakly constrain when motor cortical output influences muscle activity in the unperturbed state. Analysis of motor cortical activity has consistently found, and imputed functional significance upon, signals that correlate with limb muscle activity or kinematics. But a selective role in driving certain muscle activity patterns might rely on signals related only to those patterns and not others. Here we quantified the direct influence of forelimb motor cortex on muscle activity throughout a naturalistic climbing behavior, finding that this influence is selective for, and highly dependent upon, muscle activity states. We used multielectrode array recordings to identify linear combinations (components) of motor cortical activity patterns that covary with this influence. We find that these components differ substantially from those that covary with muscle activity or kinematics. Our results reveal a direct motor cortical influence on muscles that is selective within a motor behavior and reliant on a previously undescribed neural activity subspace.

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Towards Cell and Subtype Resolved Functional Organization: Mouse as a Model for the Cortical Control of Movement

Cited by 7 publications

References 119 publications

Neural dynamics in the rodent motor cortex enables flexible control of vocal timing

Neural dynamics in the rodent motor cortex enables flexible control of vocal timing

A cortical circuit for orchestrating oromanual food manipulation

Selective direct motor cortical influence during naturalistic climbing

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