Towards an optimal semiquantitative approach in giant cell arteritis: an 18F-FDG PET/CT case-control study

Besson, Florent L.; Boysson, Hubert de; Parienti, Jean‐Jacques; Bouvard, G.; Bienvenu, Boris; Denis, Arnaud

doi:10.1007/s00259-013-2545-1

Cited by 65 publications

(60 citation statements)

References 33 publications

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“…Six studies [21, 24, 33, 35, 40, 41] used a semiquantitative scoring method to evaluate vascular uptake (Table 3). Blockmans, in two prospective studies [21, 33], proposed a semiquantitative system that evaluates 18F-FDG uptake in 7 different vascular regions (thoracic aorta, abdominal aorta, subclavian arteries, axillary arteries, carotid arteries, iliac arteries, and femoral arteries) with the following grading: 0: no uptake; 1: minimal but not negligible uptake; 2: clearly increased uptake; and 3: very marked uptake.…”

Section: Resultsmentioning

confidence: 99%

“…In their retrospective controlled study [41], Besson et al compared three different semiquantitative approaches. The first method was derived from that described by Hautzel et al [35], including two variants for normalizing the arterial activity to the liver uptake (i.e., highest SUVmax vascular/liver ratio and average SUVmax vascular/liver ratio) [35, 41].…”

Section: Resultsmentioning

confidence: 99%

“…The first method was derived from that described by Hautzel et al [35], including two variants for normalizing the arterial activity to the liver uptake (i.e., highest SUVmax vascular/liver ratio and average SUVmax vascular/liver ratio) [35, 41]. The second approach was adapted from that described by Moosig et al [29] and included two variants, where the arterial activity was normalized to the lung uptake (i.e., highest SUVmax vascular/lung ratio and average SUVmax vascular/lung ratio).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Giant Cell Arteritis: A Systematic Review of the Qualitative and Semiquantitative Methods to Assess Vasculitis with 18F-Fluorodeoxyglucose Positron Emission Tomography

Puppo

Massollo

Paparo

et al. 2014

BioMed Research International

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Giant cell arteritis (GCA) is the most common vasculitis affecting medium and large vessels. It shows a close clinical association with polymyalgia rheumatica (PMR), a musculoskeletal inflammatory disorder, which is clinically characterized by girdles pain and stiffness. 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is an effective tool for the diagnosis, grading, and follow-up of patients affected by GCA involving the aorta and its proximal branches, but the lack of a standardized method for the assessment of vascular inflammation remains a critical issue, potentially leading to misclassification. In our systematic review, including 19 original articles for a total of 442 GCA patients (with or without PMR symptoms) and 535 healthy controls, we described the different qualitative, semiquantitative and combined methods that have been proposed throughout the literature for assessing the presence and grading the severity of GCA-related vascular inflammation on 18F-FDG PET scans, focusing on the diagnostic performance and examining their respective advantages and limitations. The majority of the included studies adopted qualitative methods of PET image analysis, which are less sensitive but more specific than semiquantitative ones. Among the semiquantitative approaches, the aortic-to-blood pool uptake ratio of the aortic arch seems to be the most accurate method.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Giant Cell Arteritis: A Systematic Review of the Qualitative and Semiquantitative Methods to Assess Vasculitis with 18F-Fluorodeoxyglucose Positron Emission Tomography

Puppo

Massollo

Paparo

et al. 2014

BioMed Research International

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“…On the contrary, there was only one patient with large vessel GCA in whom the aorta was spared [15]. 18 F-fl uorodeoxyglucose positron emission tomography (PET) might have a higher sensitivity for aortic involvement in the disease and shows larger extension of infl ammatory areas than CT [16]. PET is of special value if isolated GCA-aortitis is considered and if active infl ammation is suspected although laboratory infl ammation parameters are normal.…”

Section: Giant Cell Arteritis (Gca)mentioning

confidence: 99%

Inflammatory diseases of the aorta

Caspary

2016

Vasa

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Summary:Infl ammatory aortic diseases may occur with and without dilatation and are complicated by obstruction, rupture and dissection. Infections originate from periaortic foci or septicaemia and tend to result in the rapid development of aneurysms. Large vessel vasculitis due to Takayasu arteritis in younger and giant cell arteritis (GCA) in older patients is located in all layers of the aortic wall and prevails in the thoracic section. GCA patients are prone to developing aortic complications in the late course of disease. In Behçet's disease, aneurysms may have an unusual morphology and localisation. The diagnosis of aortitis is usually obtained by vascular imaging, but partly made only by biopsy on occasion of an operation, especially in case of isolated aortitis of the ascending aorta which mostly remains inapparent until dissection or large aneurysms have developed. Periaortitis typically occurs in the abdominal aorta and may lead to infl ammatory aortic aneurysm (IAA). It is looked upon as a special form of vasculitis, with an overlap to primary retroperitoneal fi brosis (RF). An identical pathology is discussed for the three diseases. On the other hand, about 50 % of isolated aortitides and periaortitides as well as retroperitoneal fi broses can be classed among IgG4-related diseases. Periaortitis also is observed after treatment of aortic aneurysms by stent-graft implantation. Special attention should be paid to ureteral obstruction along with RF or IAA. Once infection is ruled out, immunosuppression is applied to all forms of infl ammatory aortic diseases, primarily with glucocorticoids. However, after successful surgery for isolated thoracic aortitis or infl ammatory aortic aneurysm immunosuppression may be dispensable and it is not required if periaortic tissue enlargement persists in chronic inactive disease. For some patients with periaortitis and RF, tamoxifen may be a valuable alternative.

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“…Some issues, however, have not been fully analysed. While many papers focused their attention on the diagnostic accuracy of the procedure and its ability to bring about a clinical diagnosis, even though the lack of a standard criterion for positivity (visual analysis of the images, various semi-quantitative parameters) remains an open problem [21][22][23][24][25], the number of works about the prognostic power of the technique is substantially inferior [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of baseline 18F-FDG PET/CT in steroid-naïve large-vessel vasculitis: introduction of volume-based parameters

Dellavedova

Carletto

Faggioli

et al. 2015

Eur J Nucl Med Mol Imaging

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Towards an optimal semiquantitative approach in giant cell arteritis: an 18F-FDG PET/CT case-control study

Abstract: Among all tested (18)F-FDG PET/CT methods, the aortic to blood pool SUVmax ratio outperformed the liver and lung ratios. We suggest the use of this ratio for the assessment of aortic inflammation in GCA patients.

Cited by 65 publications

References 33 publications

Giant Cell Arteritis: A Systematic Review of the Qualitative and Semiquantitative Methods to Assess Vasculitis with 18F-Fluorodeoxyglucose Positron Emission Tomography

Giant Cell Arteritis: A Systematic Review of the Qualitative and Semiquantitative Methods to Assess Vasculitis with 18F-Fluorodeoxyglucose Positron Emission Tomography

Inflammatory diseases of the aorta

The prognostic value of baseline 18F-FDG PET/CT in steroid-naïve large-vessel vasculitis: introduction of volume-based parameters

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