Towards an adiposity-related disease framework for the diagnosis and management of obesities

Perdomo, Carolina M; Avilés-Olmos, Icíar; Dicker, Dror; Frühbeck, Gema

doi:10.1007/s11154-023-09797-2

Cited by 11 publications

(5 citation statements)

References 138 publications

(147 reference statements)

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“…The participants in this study were obese students who were filtered based on particular criteria so that their being homogeneous in representing health status-related obesity. It is already known that obesity is a complex disease (Perdomo et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

Improvement of serum cortisol levels in obese female college students after moderate-intensity acute exercise

Puspitorini,

Soemardiawan,

Annamayra

et al. 2023

SPORTIF

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Obesity is a condition that can cause metabolic stress by activating the HPA axis, which impacts increasing stress levels characterized by increased cortisol secretion. The present research aims to investigate the impact of moderate-intensity acute exercise on decreasing cortisol levels among obese female students. A true-experimental method with a pretest-posttest control group design was utilized to conduct the study. A total of 20 female students between the ages of 20 and 23, with a BMI ranging from 25-28 kg/m2, voluntarily participated in the research. The participants were divided into two groups: control (n=10) and exercise (n=10) - the latter group being exposed to moderate-intensity acute exercise once as an intervention, with 40-minute sessions and an intensity level of 60-70% HRmax using the Treadmill Life Fitness equipment. The serum cortisol levels were measured through the ELISA 30 minutes pre-exercise and 6 hours post-exercise. The collected data were analyzed using an independent sample t-test with a 5% significance level. The study's findings will help compare the mean serum cortisol levels between the control and exercise groups. Based on the results of the study, it was found it can be concluded that moderate-intensity acute exercise carried out for 40 minutes/exercise session was effective in reducing serum cortisol levels in obese female students. We recommend exercise to overcome stress-related metabolic health problems in individuals with obesity.

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Section: Methodsmentioning

confidence: 99%

Improvement of serum cortisol levels in obese female college students after moderate-intensity acute exercise

Puspitorini,

Soemardiawan,

Annamayra

et al. 2023

SPORTIF

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“…Several scientific societies are currently working on developing new working frameworks to better capture the reality of excess weight and its appropriate management. 5,[20][21][22][23] On the one hand, the simplicity of the measurement of weight, height, waist, hip and combinations to derive anthropometric indices makes it useful in clinical as well epidemiological settings. On the other hand, being a mere surrogate of adiposity the right balance between usefulness and meaningfulness needs to be struck.…”

Section: Reframing Obesitymentioning

confidence: 99%

Revisiting the beyond BMI paradigm in excess weight diagnosis and management: A call to action

Aguas‐Ayesa,

Yárnoz‐Esquiroz,

Perdomo

et al. 2024

Eur J Clin Investigation

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Adolphe Quételet, a 19th‐century Belgian sociologist and statistician, pioneered the incorporation of statistics into social sciences. He initiated the development of anthropometry since he was interested in identifying the proportions of the ‘ideal man’. He devised a ratio between weight and height, originally termed the Quételet Index, and today widely known and used as the body mass index or BMI. In 1835, he demonstrated that a normal curve accommodates the distribution of human traits articulating his reasoning on human variance around the average. Quételet's long‐lasting legacy of the establishment of a simple measure to classify people's weight relative to an ideal for their height endures today with minor variations having dramatically influenced public health agendas. While being very useful, the limitations of the BMI are well known. Thus, revisiting the beyond BMI paradigm is a necessity in the era of precision medicine with morphofunctional assessment representing the way forward via incorporation of body composition and functionality appraisal. While healthcare systems were originally designed to address acute illnesses, today's demands require a radical rethinking together with an original reappraisal of our diagnosis and treatment approaches from a multidimensional perspective. Embracing new methodologies is the way forward to advance the field, gain a closer look at the underlying pathophysiology of excess weight, keep the spotlight on improving diagnostic performance and demonstrate its clinical validity. In order to provide every patient with the most accurate diagnosis together with the most appropriate management, a high degree of standardization and personalization is needed.

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“…Moreover, epidemiological forecasts from the United States suggest that obesity prevalence in the adult demographic is poised to reach 49% by 2030 [2]. Concurrently, there is a marked annual rise in the incidence of obesity-associated comorbidities, such as type 2 diabetes, hypertension, obstructive sleep apnoea, non-alcoholic fatty liver disease, and cardiovascular diseases [3].…”

Section: Introductionmentioning

confidence: 99%

The Causal Relationship between Obesity and Myasthenia Gravis: A Two-Sample and Multivariate Study

Yang,

Li,

Yang

et al. 2024

Preprint

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Background Observational studies have identified a correlation between obesity and myasthenia gravis. Nonetheless, the causality of this relationship is debated. To address this, we employed Two-sample Mendelian Randomization (MR) to investigate the causal influences of obesity-related metrics on myasthenia gravis and its subtypes. Methods We retrieved the summary statistics of exposure-related single nucleotide polymorphisms (SNPs) from publicly available genome-wide association study abstracts, and the aggregate data of myasthenia gravis and its subtypes came from the largest genome-wide association studies, to conduct univariate and multivariate MR analyses. In the primary MR analysis, we used the inverse variance weighted (IVW) method, followed by weighted median, mode-based estimation, and MR-Egger regression. We further assessed the robustness of the results through a series of sensitivity analyses including MR pleiotropy residual sum and outlier (MR-PRESSO) test to detect the stability of the outcomes. Reverse MR analysis was also performed. Results Analysis revealed that obesity-related body composition metrics were initially linked to a heightened risk of myasthenia gravis. However, subsequent adjustments revealed that only hip circumference (Inverse Variance Weighted Odds Ratio (IVW OR = 1.67, 95% CI: 1.29 to 2.71, P < 0.001) and whole body fat mass (IVW OR = 1.60, 95% CI: 1.22 to 2.09, P < 0.001) exerted a significant detrimental causal effect on myasthenia gravis. In contrast, other obesity-related metrics did not demonstrate an increased risk for Late-Onset Myasthenia Gravis (LOMG) (IVW OR = 1.65, 95% CI: 1.22 to 2.24, P = 0.001), nor did obesity correlate with an increased risk of Early-Onset Myasthenia Gravis (EOMG). Further adjustments for genetic predisposition to diabetes in the multivariate analysis affirmed the significant association between hip circumference, whole body fat mass, and both types of myasthenia gravis. Additionally, reverse Mendelian Randomization analysis indicated that EOMG might elevate the risk associated with arm and leg fat mass. Conclusion Our findings reinforce the concept that obesity detrimentally influences myasthenia gravis, underscoring the imperative of incorporating obesity management into therapeutic strategies for this condition. Prospective investigations are essential to delineate the efficacy of obesity intervention in the prophylaxis of myasthenia gravis.

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Towards an adiposity-related disease framework for the diagnosis and management of obesities

Cited by 11 publications

References 138 publications

Improvement of serum cortisol levels in obese female college students after moderate-intensity acute exercise

Improvement of serum cortisol levels in obese female college students after moderate-intensity acute exercise

Revisiting the beyond BMI paradigm in excess weight diagnosis and management: A call to action

The Causal Relationship between Obesity and Myasthenia Gravis: A Two-Sample and Multivariate Study

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