Towards advanced biological detection using surface enhanced raman scattering (SERS)-based sensors

Hankus, Mikella E.; Stratis‐Cullum, Dimitra N.; Pellegrino, Paul M.

doi:10.1117/12.859267

Cited by 18 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different to our nanopore-cavity structures, the Klarite substrate has four hot spot regions located at the top edges and one at the bottom vertex. 48 , 49 These hot spots have similar local optical intensities, but all are weaker than that inside our nanopore-cavities. To figure out the wetting situation of the bottom vertex of Klarite substrates, we introduced our priming method.…”

Section: Resultsmentioning

confidence: 78%

Full wetting of plasmonic nanopores through two-component droplets

Chang

et al. 2015

Chem. Sci.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 78%

Full wetting of plasmonic nanopores through two-component droplets

Chang

et al. 2015

Chem. Sci.

View full text Add to dashboard Cite

show abstract

“…Raman and Raman-based detection systems rely on specific vibrations within a molecule from which a fingerprint spectrum is produced 14,60,78,79,[81][82][83][84][85][86][87][88][89][90][91][92] . This fingerprint spectrum can be used for the identification, and in some cases quantification, of unknown materials.…”

Section: Brief Review Of Some Current Techniques Utilized For the Detmentioning

confidence: 99%

“…Some examples of SERS substrate fabrication include self-assembly through such techniques like drop and dry, directed or templated assembly, thin film growth, and nanolithography. It is suggested that the reader look to several comprehensive reviews and interesting papers for a more complete discussion of SERS substrate fabrication techniques, applications, advantages and challenges3,11,17,24,33,84,85,[108][109][110][111][112][113][114][115][116][117][118][119][120][121] .…”

mentioning

confidence: 99%

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

2015

Self Cite

View full text Add to dashboard Cite

Generally the fabrication, assembly and evaluation of plasmonic nanostructures for surface enhanced Raman scattering (SERS) substrates has focused on static rigid substrates such as glass and silicon. However, these static substrates severely limit the application of plasmonic nanostructures as (i) they provide no means to alter the state of assembly of the nanostructures once they are formed or anchored on the surface i.e., not reconfigurable; and (ii) preclude applications which demand non-planar, flexible or conformal surfaces. The above considerations has led to the development of a novel class of SERS substrates based on flexible substrates such paper, polymer membranes and electrospun fibers. These flexible SERS media based on unconventional substrates such as paper offer distinct advantages compared to the conventional SERS substrates in that (i) flexible nature of the substrate enables conformal contact with the surfaces under investigation leading to efficient sample collection; (ii) porous nature of the SERS substrate (interstices between the fibers) provides efficient access to the analytes; (iii) high surface area of the 3D paper substrate results in large dynamic range of the chemical sensors; (iv) intricate network of fibers decorated with metal nanoparticles can provide potentially high density of electromagnetic hotspots; (v) intense light scattering caused by the fibrous structure of the substrate (e.g., paper) enables efficient light-metal interaction; and (vi) facile fabrication leads to efficient, robust, reliable, reusable and cost-effective SERS substrates. In this presentation, we will focus on the Army need for a more flexible (substrate surface and application) SERS substrate for universal sensing. This presentation will leverage from material presented at a flexible SERS (May 2014) workshop hosted by Dr. Srikanth Singamaneni at Washington University.

show abstract

“…It is suggested that the reader look to several comprehensive reviews and interesting papers for a more complete discussion of SERS substrate fabrication techniques, applications, advantages and challenges. 1,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] One of the more common and easily achieved methods for the fabrication of SERS substrates is known as the drop and dry technique. Drop and dry techniques or Film over Nanosphere (FONS) offer some advantages as compared to other fabrication methods like ease of fabrication due to cheaper manufacturing materials, and often being lower cost in skill, time and overall materials as compared to some other more fabrication intensive techniques.…”

Section: Example Sers Substratesmentioning

confidence: 99%

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

et al. 2016

Self Cite

View full text Add to dashboard Cite

The utility of peptide-based molecular sensing for the development of novel biosensors has resulted in a significant increase in their development and usage for sensing targets like chemical, biological, energetic and toxic materials. Using peptides as a molecular recognition element is particularly advantageous because there are several mature peptide synthesis protocols that already exist, peptide structures can be tailored, selected and manipulated to be highly discerning towards desired targets, peptides can be modified to be very stable in a host of environments and stable under many different conditions, and through the development of bifunctionalized peptides can be synthesized to also bind onto desired sensing platforms (various metal materials, glass, etc.). Two examples of the several Army relevant biological targets for peptide-based sensing platforms include Ricin and Abrin. Ricin and Abrin are alarming threats because both can be weaponized and there is no antidote for exposure. Combining the sensitivity of SERS with the selectivity of a bifunctional peptide allows for the emergence of dynamic hazard sensor for Army application.

show abstract

Towards advanced biological detection using surface enhanced raman scattering (SERS)-based sensors

Cited by 18 publications

References 0 publications

Full wetting of plasmonic nanopores through two-component droplets

Full wetting of plasmonic nanopores through two-component droplets

Flexible SERS-based substrates: challenges and opportunities toward an Army relevant universal sensing platform

The development of Army relevant peptide-based surface enhanced Raman scattering (SERS) sensors for biological threat detection

Contact Info

Product

Resources

About