Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime

Abstract

Towards accurate and label-free monitoring of bio-analytes using supercontinuum based multispectral photoacoustic spectroscopy in the extended near-infrared wavelength regime," ABSTRACTIn this work, we report a cost-effective supercontinuum (SC) laser-based multispectral photoacoustic spectroscopy (MSPAS) system for studying spectral characteristics of various analytes. We demonstrate an in vitro label-free monitoring of the analytes in the extended near-infrared (NIR) (1540-1840 nm) spectral range. We further demonstrate how a simple ratiometric analysis in conjunction with linear regression can be used for accurate prediction of glucose over commonly encountered physiological levels inside the human body (0-400 mg/dL). Looking forward, the proposed SC-based MSPAS system provides a framework for the development of label-free and non-invasive monitoring multiple bio-analytes accurately, with potential translation to clinical in vivo applications.