Towards a ‘systems’-level understanding of the nervous system and its disorders

Qureshi, Irfan A.; Mehler, Mark F.

doi:10.1016/j.tins.2013.07.003

Cited by 40 publications

(32 citation statements)

References 116 publications

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“…Owing to its intravascular location, the BBB is prone to incursions by circulating inflammatory signals [9, 27, 43-46]. These attacks could be facilitated by increased expression of adhesion molecules on endothelial cells seen in epileptic brain [47].…”

Section: Inflammatory Mechanisms Involved In Blood-brain Barrier Disrmentioning

confidence: 99%

Inflammatory pathways of seizure disorders

Marchi

Granata

Janigro

2014

Trends in Neurosciences

203

133

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Epilepsy refers to a cluster of neurological disease characterized by seizures. While many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an altered immune response is only suspected. In general, the hypothesis that inflammation contributes to seizures is supported by experimental results. Additionally, antiepileptic maneuvers may act as immunomodulators and anti-inflammatory therapies can treat seizures. Triggers of seizure include a bidirectional communication between the nervous system and organs of immunity. Thus, a crucial cellular interface protecting from immunological seizures is the blood-brain barrier. Here, we summarize recent advances in the understanding and treatment of epileptic seizures which derive from a non-neurocentric viewpoint and suggest key avenues for future research.

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Section: Inflammatory Mechanisms Involved In Blood-brain Barrier Disrmentioning

confidence: 99%

Inflammatory pathways of seizure disorders

Marchi

Granata

Janigro

2014

Trends in Neurosciences

203

133

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“…Along with the realization that a better understanding of human disease mechanisms requires an investigation of networks [53] in order to gain a holistic view of brain and central nervous system dysfunction [54], modeling tools for pathway changes are used to integrate information acquired from proteomics and metabolomics experiments [55]. The complex molecular underpinnings of psychiatric disorders are reflected by a combination of mild quantitative molecular changes rather than by a few prominent biomarkers.…”

Section: Proteomics and Metabolomics Studies In Psychiatric Disordersmentioning

confidence: 99%

What Have Mass Spectrometry-Based Proteomics and Metabolomics (Not) Taught Us about Psychiatric Disorders?

Turck

Filiou

2015

Complex Psychiatry

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Understanding the molecular causes and finding appropriate therapies for psychiatric disorders are challenging tasks for research; -omics technologies are used to elucidate the molecular mechanisms underlying brain dysfunction in a hypothesis-free manner. In this review, we will focus on mass spectrometry-based proteomics and metabolomics and address how these approaches have contributed to our understanding of psychiatric disorders. Specifically, we will discuss what we have learned from mass spectrometry-based proteomics and metabolomics studies in rodent models and human cohorts, outline current limitations and discuss the potential of these methods for future applications in psychiatry.

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“…Moreover, extracellular epigenetic signaling seems to be involved in mediating communication between central and peripheral circadian clocks. Systems level analyses are necessary to better define the relationships between the whole organism circadian system, associated physiological processes, and related comorbidities [88]. The rapidly evolving field of epigenetics provides a robust framework for doing so across central and peripheral tissues and also promises to identify pharmacological and other treatment strategies that are novel and based on integrative molecular mechanisms.…”

Section: Perspectivesmentioning

confidence: 99%

Epigenetics of Sleep and Chronobiology

Qureshi

Mehler

2014

Curr Neurol Neurosci Rep

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The circadian clock choreographs fundamental biological rhythms. This system is comprised of the master circadian pacemaker in the suprachiasmatic nucleus and associated pacemakers in other tissues that coordinate complex physiological processes and behaviors, such as sleep, feeding, and metabolism. The molecular circuitry that underlies these clocks and orchestrates circadian gene expression has been the focus of intensive investigation, and it is becoming clear that epigenetic factors are highly integrated into these networks. In this review, we draw attention to the fundamental roles played by epigenetic mechanisms in transcriptional and post-transcriptional regulation within the circadian clock system. We also highlight how alterations in epigenetic factors and mechanisms are being linked with sleep-wake disorders. These observations provide important insights into the pathogenesis and potential treatment of these disorders and implicate epigenetic deregulation in the significant but poorly understood interconnections now emerging between circadian processes and neurodegeneration, metabolic diseases, cancer, and aging.

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Towards a ‘systems’-level understanding of the nervous system and its disorders

Cited by 40 publications

References 116 publications

Inflammatory pathways of seizure disorders

Inflammatory pathways of seizure disorders

What Have Mass Spectrometry-Based Proteomics and Metabolomics (Not) Taught Us about Psychiatric Disorders?

Epigenetics of Sleep and Chronobiology

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