Towards a simple <i>in vitro</i> surface chemistry pre-screening method for nanoparticles to be used for drug delivery to solid tumours

Schmid, Roman; Kaiser, Juliane; Willbold, Ramona; Walther, Nomusa; Wittig, Rainer; Lindén, Mika

doi:10.1039/d3bm00966a

Biomater. Sci.

2023

DOI: 10.1039/d3bm00966a

|View full text |Cite

Towards a simple in vitro surface chemistry pre-screening method for nanoparticles to be used for drug delivery to solid tumours

Roman Schmid

Juliane Kaiser²,

Ramona Willbold³

et al.

Abstract: An efficient nanoparticulate drug carrier intended for chemotherapy based on intravenous administration must exhibit a long enough blood circulation time, a good penetrability into the tumour volume, as well as...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 59 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†

Li,

Xiao,

Jin

et al. 2024

Chin. J. Chem.

View full text Add to dashboard Cite

Comprehensive SummaryThe structural and surface properties of nanomedicines play an important role in determining their biological fate. Surface chemistry of nanomedicines is one of the key parameters, where researchers used various strategies such as PEGylation to avoid the undesired clearance of nanoparticles (NPs) for enhanced targeting effect. Nevertheless, the fine‐tuning of surface chemistry through polymer functionalization remains largely unexplored. In this concise report, we find that the incorporation of only 10 mol% valine residues into the surface‐anchored poly(L‐glutamic acid) significantly lowered the macrophage uptake of NPs. The introduction of other hydrophobic amino acid residues, however, increased the NPs internalization instead. The chirality and the side‐chain structure of valine played an important role in the unexpected uptake behavior. We believe this work highlights the impact of slight changes of the surface‐anchored polymer structure on the behavior of NPs, drawing people's attention to the careful design of surface chemistry to optimize the nanomedicine design.

show abstract

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†

Li,

Xiao,

Jin

et al. 2024

Chin. J. Chem.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Towards a simple in vitro surface chemistry pre-screening method for nanoparticles to be used for drug delivery to solid tumours

Abstract: An efficient nanoparticulate drug carrier intended for chemotherapy based on intravenous administration must exhibit a long enough blood circulation time, a good penetrability into the tumour volume, as well as...

Cited by 1 publication

References 59 publications

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†

Contact Info

Product

Resources

About

Towards a simple in vitro surface chemistry pre-screening method for nanoparticles to be used for drug delivery to solid tumours

Abstract: An efficient nanoparticulate drug carrier intended for chemotherapy based on intravenous administration must exhibit a long enough blood circulation time, a good penetrability into the tumour volume, as well as...

Cited by 1 publication

References 59 publications

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues†

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues†

Contact Info

Product

Resources

About

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†

Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues^†