Towards a Self‐Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

Renaudet, Olivier; BenMohamed, Lbachir; Dasgupta, Gargi; Bettahi, Ilham; Dumy, Pascal

doi:10.1002/cmdc.200700315

Cited by 100 publications

(89 citation statements)

References 41 publications

(17 reference statements)

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“…All peptides were aliquoted and stored at Ϫ20°C until assayed. All in vivo immunization studies were conducted with the immunogen emulsified in CpG 1826 adjuvant, which was immediately injected subcutaneously into mice as recently described (10,12,53,62).…”

Section: Study Population From August 2003 To October 2007 We Screementioning

confidence: 99%

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Zhang

Castelli

Zhu

et al. 2008

Clin Vaccine Immunol

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Section: Study Population From August 2003 To October 2007 We Screementioning

confidence: 99%

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Zhang

Castelli

Zhu

et al. 2008

Clin Vaccine Immunol

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“…Dumy et al capitalized on these cumulated observations toward the achievement of a fully synthetic fourcomponent antitumoral vaccine (24, Figure 10), built on a non-immunogenic cyclodecapeptide template (known as "RAFT" for "Regioselectively Addressable Functionalized Templates) (Dumy et al, 1995;Renaudet et al, 2008;Renaudet et al, 2010;Fiore et al, 2013). The optimized multiepitopic construct incorporated four copies of a T N antigen analogue as B cell epitope, the universal CD4 + helper T-cell peptide from the type I-poliovirus protein together with a CD8 + CTL from ovalbumin (OVA [257][258][259][260][261][262][263][264] peptide SIINFEKL) to which was covalently added palmitic acid as lipid adjuvant.…”

Section: Other Related Tf-antigen Vaccinesmentioning

confidence: 99%

Glycodendrimers: versatile tools for nanotechnology

Roy

Shiao

Rittenhouse-Olson

2013

Braz. J. Pharm. Sci.

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Combining nanotechnology with glycobiology has triggered an exponential growth of research activities in the design of novel functional bionanomaterials (glyconanotechnology). More specifically, recent synthetic advances towards the tailored and versatile design of glycosylated nanoparticles namely glyconanoparticles, considered as synthetic mimetics of natural glycoconjugates, paved the way toward diverse biomedical applications. The accessibility of a wide variety of these structured nanosystems, in terms of shapes, sizes, and organized around stable nanoparticles have readily contributed to their development and applications in nanomedicine. In this context, glycosylated gold-nanoparticles (GNPs), glycosylated quantum dots (QDs), fullerenes, single-wall natotubes (SWNTs), and self-assembled glycononanoparticles using amphiphilic glycopolymers or glycodendrimers have received considerable attention to afford powerful imaging, therapeutic, and biodiagnostic devices. This review will provide an overview of the most recent syntheses and applications of glycodendrimers in glycoscience that have permitted to deepen our understanding of multivalent carbohydrate-protein interactions. Together with synthetic breast cancer vaccines, inhibitors of bacterial adhesions to host tissues including sensitive detection devices, these novel bionanomaterials are finding extensive relevance.

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“…+ -Th-Epitop, ein CD8 + -CtlPeptid-Epitop und einen Palmitinsäurerest, der als eingebautes Adiuvans wirkt (Abbildung 22 b6) [338] Dieser Impfstoff provozierte erfolgreich die Bildung starker Tn-spezifischer IgG/IgM-Antikçrper. Die eingebauten PADRE-und OVA 257-…”

Section: Tumorassoziierte O-glycane Vom Mucintypunclassified

Auf dem Weg zur automatisierten Oligosaccharid‐ Synthese

Hsu

Hung

et al. 2011

Angewandte Chemie

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Kohlenhydrate spielen eine wichtige Rolle bei biologischen Vorgängen. Das Fortschrittstempo der Kohlenhydratforschung ist jedoch relativ langsam, was unter anderem mit der Komplexität der Kohlenhydratstrukturen und dem Fehlen allgemein anwendbarer Synthesemethoden und Verfahren zur Untersuchung dieser Klasse von Biomolekülen zusammenhängt. Jüngste Fortschritte in der Synthese haben ergeben, dass viele dieser Probleme umgangen werden können. In diesem Aufsatz beschreiben wir die Methoden, die entwickelt wurden, um mit den Herausforderungen kohlenhydratvermittelter biologischer Vorgänge umzugehen. Besonderes Augenmerk wird dabei auf die Entwicklung der automatisierten Synthese von Oligosacchariden gerichtet. Darüber hinaus werden auch Kohlenhydrat‐Mikroarrays und Impfstoffe auf Kohlenhydratbasis behandelt.

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Towards a Self‐Adjuvanting Multivalent B and T cell Epitope Containing Synthetic Glycolipopeptide Cancer Vaccine

Cited by 100 publications

References 41 publications

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Gender-Dependent HLA-DR-Restricted Epitopes Identified from Herpes Simplex Virus Type 1 Glycoprotein D

Glycodendrimers: versatile tools for nanotechnology

Auf dem Weg zur automatisierten Oligosaccharid‐ Synthese

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