Towards a revised generic classification of lecanoroid lichens (Lecanoraceae, Ascomycota) based on molecular, morphological and chemical evidence

Zhao, Xin; Leavitt, Steven D.; Zhao, Zhanxiang; Zhang, Lu Lu; Arup, Ulf; Grube, Martín; Pérez‐Ortega, Sergio; Printzen, Christian; Śliwa, Lucyna; Kraichak, Ekaphan; Divakar, Pradeep K.; Crespo, Ana; Lumbsch, H. Thorsten

doi:10.1007/s13225-015-0354-5

Cited by 87 publications

(137 citation statements)

References 69 publications

Supporting

Mentioning

129

Contrasting

Unclassified

Order By: Relevance

“…Molecular phylogenetic studies -such as the present one -are therefore essential for revealing occurrences of convergent evolution or parallelism within these traditionally morphology-based classifications, and to guide taxonomic genus delimitation. Similar instances of polyphyly can be found throughout several other lichen families and genera (e.g., Divakar & al., 2006;Bendiksby & Timdal, 2013;Kirika & al., 2016;Zhao & al., 2016). In our study, we show that phenotypic features, such as the growth form or the presence of a prothallus, are often a result of adaptation to a Table 2.…”

Section: Discussionmentioning

confidence: 99%

Molecular systematics and character evolution in the lichen family Ramalinaceae (Ascomycota: Lecanorales)

Kistenich

Timdal

Bendiksby

et al. 2018

TAXON

169

View full text Add to dashboard Cite

The Ramalinaceae is the fourth-largest family of lichenized ascomycetes with 42 genera and 913 species exhibiting considerable morphological variation. Historically, generic boundaries in the Ramalinaceae were primarily based on morphological characters. However, molecular systematic investigations of subgroups revealed that current taxonomy is at odds with evolutionary relationships. Tropical members of the family remain particularly understudied, including the large genus Phyllopsora. We have generated and collected multilocus sequence data (mtSSU, nrITS, nrLSU, RPB1, RPB2) for 149 species associated with the Ramalinaceae and present the first comprehensive molecular phylogeny of the family. We used ancestral state reconstructions on our molecular family phylogeny to trace the evolution of character states. Our results indicate that the Ramalinaceae have arisen from an ancestor with long, multiseptate ascospores living in humid temperate forests, and that the phyllopsoroid growth form has evolved multiple times within the family. Based on our results using integrative taxonomy, we discuss sister-relations and taxon-delimitation within five well-supported clades: The Bacidia, Biatora-, Ramalina-, Rolfidium-, and Toninia-groups. We reduce six genera into synonymy and make 49 new nomenclatural combinations. The genera Bacidia, Phyllopsora, Physcidia and Toninia are polyphyletic and herein split into segregates. We describe the two genera Bellicidia and Parallopsora and resurrect the genera Bibbya, Kiliasia, Sporacestra, and Thalloidima. According to our new circumscription, which also includes some additional changes, the family Ramalinaceae now comprises 39 genera.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular systematics and character evolution in the lichen family Ramalinaceae (Ascomycota: Lecanorales)

Kistenich

Timdal

Bendiksby

et al. 2018

TAXON

169

View full text Add to dashboard Cite

show abstract

“…Cancer cells can undergo genotoxic stress as a result of threats to DNA structure and genome instability. [107][108][109][110][111] The threats can arise from a broad range of events and agents, including unresolved replication fork stalling during normal DNA replication, accumulation of metabolic intermediates (e.g. ROS) that are highly reactive to DNA, and exposure to chemotherapy or radiation therapy.…”

Section: Genotoxic Stressmentioning

confidence: 99%

Therapeutic targeting of cellular stress responses in cancer

Chen

Xie

2018

Thoracic Cancer

View full text Add to dashboard Cite

Similar to bacteria, yeast, and other organisms that have evolved pathways to respond to environmental stresses, cancer cells develop mechanisms that increase genetic diversity to facilitate adaptation to a variety of stressful conditions, including hypoxia, nutrient deprivation, exposure to DNA‐damaging agents, and immune responses. To survive, cancer cells trigger mechanisms that drive genomic instability and mutation, alter gene expression programs, and reprogram the metabolic pathways to evade growth inhibition signaling and immune surveillance. A deeper understanding of the molecular mechanisms that underlie the pathways used by cancer cells to overcome stresses will allow us to develop more efficacious strategies for cancer therapy. Herein, we overview several key stresses imposed on cancer cells, including oxidative, metabolic, mechanical, and genotoxic, and discuss the mechanisms that drive cancer cell responses. The therapeutic implications of these responses are also considered, as these factors pave the way for the targeting of stress adaption pathways in order to slow cancer progression and block resistance to therapy.

show abstract

“…In addition, an efficient method has been developed to screen for mutants capable of adapting to abnormal salt gland density . In addition to the morphology of these specialized structures, the K + /Na + ratio has been shown to play an important role in Limonium bicolor salt tolerance . Accumulation of K + in the cytoplasm and nucleus of salt gland cells is a key factor in salt secretion …”

Section: Salt Stressmentioning

confidence: 99%

“…31 In addition to the morphology of these specialized structures, the K + /Na + ratio has been shown to play an important role in Limonium bicolor salt tolerance. [102][103][104][105][106][107] Accumulation of K + in the cytoplasm and nucleus of salt gland cells is a key factor in salt secretion. 108 In addition to halophytes, many other plants also exhibit adaptations to protect against salt stress.…”

Section: Salt Stressmentioning

confidence: 99%

Molecular mechanisms underlying stress response and adaptation

Sun

Zhou

2017

Thoracic Cancer

View full text Add to dashboard Cite

Environmental stresses are ubiquitous and unavoidable to all living things. Organisms respond and adapt to stresses through defined regulatory mechanisms that drive changes in gene expression, organismal morphology, or physiology. Immune responses illustrate adaptation to bacterial and viral biotic stresses in animals. Dysregulation of the genotoxic stress response system is frequently associated with various types of human cancer. With respect to plants, especially halophytes, complicated systems have been developed to allow for plant growth in high salt environments. In addition, drought, waterlogging, and low temperatures represent other common plant stresses. In this review, we summarize representative examples of organismal response and adaptation to various stresses. We also discuss the molecular mechanisms underlying the above phenomena with a focus on the improvement of organismal tolerance to unfavorable environments.

show abstract

Towards a revised generic classification of lecanoroid lichens (Lecanoraceae, Ascomycota) based on molecular, morphological and chemical evidence

Cited by 87 publications

References 69 publications

Molecular systematics and character evolution in the lichen family Ramalinaceae (Ascomycota: Lecanorales)

Molecular systematics and character evolution in the lichen family Ramalinaceae (Ascomycota: Lecanorales)

Therapeutic targeting of cellular stress responses in cancer

Molecular mechanisms underlying stress response and adaptation

Contact Info

Product

Resources

About