Towards a portable point-of-use blood analysis with EIS technique device

Punter-Villagrasa, Jaime; Moral-Zamora, Beatriz del; Colomer‐Farrarons, Jordi; Miribel-Català, Pere Ll.; Cid, Joan; Rodriguez-Villarreal, Ivon; Prieto‐Simón, Beatriz

doi:10.1109/ssd.2014.6808825

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…The whole system and the impedance detection performance has been validated using passive components and ferrocyanide/ferricyanide solution. These preliminary studies have been previously published [34].…”

Section: System Descriptionmentioning

confidence: 99%

Toward an Anemia Early Detection Device Based on 50-μL Whole Blood Sample

Punter-Villagrasa

Cid

Colomer‐Farrarons

et al. 2015

IEEE Trans. Biomed. Eng.

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A first approach to a portable and compact device for point-of-care (PoC) early instantaneous detection of anemia is described. This device works directly with whole blood samples relying on hematocrit analysis by means of impedance analysis. This device consists of a custom electronic instrumentation, postprocessing software and plug-and-play disposable sensor. The designed electronics are connected to a remote computer, which allows control of the instrumentation and results displaying with a user friendly software panel. The disposable sensor is based on a low-cost label-free three gold electrode commercial sensor for 50-μL volume samples. Forty-eight whole blood samples, randomly collected from hospitalized patients in Hospital Clínic, were used to validate the device capability for anemia detection. Whole blood samples were distributed in two groups: 10 samples for system calibration, and 38 samples for system validation. To calibrate the device, a complete EIS experiment has been performed to get a full impedance spectrum analysis, defining an accurate frequency working range for hematocrit detection. Afterward, we developed a protocol for instant impedance detection to determine the system detection accuracy, sensitivity, and coefficient of variation. As a result, impedance variations between different samples have been detected with less than 2% accuracy error for both impedance magnitude and phase. A hematocrit detection algorithm, relying on impedance analysis, has been developed based on the previous studies. The response, effectiveness, and robustness of the portable PoC device to detect anemia have been proved with an accuracy error of 1.75% and a coefficient of variation of less than 5%.

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Section: System Descriptionmentioning

confidence: 99%

Toward an Anemia Early Detection Device Based on 50-μL Whole Blood Sample

Punter-Villagrasa

Cid

Colomer‐Farrarons

et al. 2015

IEEE Trans. Biomed. Eng.

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An Audio Jack-Based Electrochemical Impedance Spectroscopy Sensor for Point-of-Care Diagnostics

et al. 2017

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Portable and easy-to-use point-of-care (POC) diagnostic devices hold high promise for dramatically improving public health and wellness. In this paper, we present a mobile health (mHealth) immunoassay platform based on audio jack embedded devices, such as smartphones and laptops, that uses electrochemical impedance spectroscopy (EIS) to detect binding of target biomolecules. Compared to other biomolecular detection tools, this platform is intended to be used as a plug-and-play peripheral that reuses existing hardware in the mobile device and does not require an external battery, thereby improving upon its convenience and portability. Experimental data using a passive circuit network to mimic an electrochemical cell demonstrate that the device performs comparably to laboratory grade instrumentation with 0.3% and 0.5° magnitude and phase error, respectively, over a 17 Hz to 17 kHz frequency range. The measured power consumption is 2.5 mW with a dynamic range of 60 dB. This platform was verified by monitoring the real-time formation of a NeutrAvidin self-assembled monolayer (SAM) on a gold electrode demonstrating the potential for POC diagnostics.

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Towards a portable point-of-use blood analysis with EIS technique device

Cited by 2 publications

References 15 publications

Toward an Anemia Early Detection Device Based on 50-μL Whole Blood Sample

Toward an Anemia Early Detection Device Based on 50-μL Whole Blood Sample

An Audio Jack-Based Electrochemical Impedance Spectroscopy Sensor for Point-of-Care Diagnostics

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