Towards a multi‐scale computerized bone diagnostic system: 2D micro‐scale finite element analysis

Podshivalov, Lev; Holdstein, Y.; Fischer, Anath; Bar‐Yoseph, P.

doi:10.1002/cnm.1214

Cited by 12 publications

(7 citation statements)

References 29 publications

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“…Our approach for multiscale finite element analysis enables continuous transition between macro-and micro-scales (Podshivalov et al, 2009) Due to changes in geometry and without updating local material properties, effective mechanical properties of bone vary at each intermediate scale. The changes range from material that is practically isotropic at the macro-scale level to anisotropic material at the micro-scale level.…”

Section: Multiscale Fe Approachmentioning

confidence: 99%

Multiscale FE method for analysis of bone micro-structures

Podshivalov

Fischer

Bar‐Yoseph

2011

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Multiscale Fe Approachmentioning

confidence: 99%

Multiscale FE method for analysis of bone micro-structures

Podshivalov

Fischer

Bar‐Yoseph

2011

Journal of the Mechanical Behavior of Biomedical Materials

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“…According to Podshivalov et al (2008) complex multilevel structure of bone tissue consists of five structural levels: Macro-structural (mm-μm) -trabecular and cortical bone tissue diameter; Microstructural (10-500 μm) -osteon and trabeculae; Sub-microstructural (1-10 μm) -lamelae and individual trabeculae; Nano-structural (100 nm-1 μm) -collagen and minerals deposited in the matrix and Sub-nanostructural (less than 100 nm) -molecular components of collagen and protein molecules. In this paper, we will focus on the macro-and microstructural level of bone structure.…”

Section: Long Bone Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Bone structure is very variable among species but also in the body of one specimen depending on bone function аnd specific factors like age, gender, general condition and lifestyle (Jowsey 1966;Mavropoulos et al 2007;Podshivalov et al 2008). For example, human vertebrae cancellous bone is mostly made of rod-like trabeculae, while the femoral head mainly consists of plate-like trabeculae (Podshivalov et al 2008). Bone structure can also A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review vary in different anatomical locations of the same bone because of different functional requirements (Wolff 1892;Hert et al 1994).…”

Section: Introductionmentioning

confidence: 99%

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A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

Cvetković¹,

Najman²,

Rajković³

et al. 2013

Vet. Med.

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Animal models are unavoidable and indispensable research tools in the fields of bone tissue engineering and experimental orthopaedics. The fact that there is not ideal animal model as well as the differences in the bone microarchitecture and physiology between animals and humans are complicate factors and make model implementation difficult. Therefore, the tendency should be directed towards extrapolation of the results from one animal model to another or from animal model to humans. So far, this is the first paper which provides an overview on the microarchitecture of lower limb long bones and discusses data related to osteon diameter, osteon canal diameter and their orientation, as well as intracortical canals and trabecular tissue microarchitecture in commonly used animal models compared to humans depending on age, gender and anatomical location of the bone. Understanding the differences between animal model and human bone microarchitecture should enable a more accurate extrapolation of experimental results from one animal model to another or from animal models to humans in the fields of bone tissue engineering and experimental orthopaedics. Also, this should be helpful in making decisions on which animal models are the most suitable for particular preclinical testing.

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“…For instance, the jagged interface and sharp corner arise when converting the image pixels into C 0 finite elements, leading to artificial localized responses such as stress concentration [5,6]. In other words, avoiding distorted elements in the process of image reconstruction and mesh generation is a tedious task [7][8][9][10]. Another issue arising from the model reconstruction process based on high-resolution medical images is the background noise and blurred objects, which could lead to incorrect numerical predictions and diagnoses due to the geometry errors in the simulation models [5,6,[10][11][12].…”

mentioning

confidence: 99%

Image‐Based Multiscale Modeling of Porous Bone Materials

Yang

Wei

Chen

2013

Multiscale Simulations and Mechanics of Biological Materials

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Bones comprise about one-fifth of an individual body weight, with the main functions in supporting and protecting organs, performing movements, and producing the blood cells, among others. Based on the microstructural composition, bones can be classified as cortical bone (compact bone) and trabecular bone (cancellous bone or spongy bone). With reference to Figure 20.1a for a femur long bone, the cortical bone constitutes about 80% of the human skeleton mass and forms an outer layer of bones, while the trabecular bone fills the interior with a porous and cancellous structure; see the microstructure of the femur long bone shown in Figure 20.1b. In general, the cortical bone is stiffer, harder, and denser than the trabecular bone so that it has the ability to protect organs and support the body movement, in addition to its ability to transmit chemical components. In contrast, the trabecular bone has a larger surface area, lower density and stiffness, and higher porosity than those of the cortical bone. Owing to the porous nature of the trabecular bone, there exists space for the blood vessels and bone marrow to flow inside the spongy structure, as can be seen from the computed tomography (CT) scan of the trabecular bone microstructure in Figure 20.2. As such, the bone materials can be characterized as porous media of solid skeleton with the pores filled with fluid. Consequently, the fluid-saturated porous material has been introduced to describe the constitutive behavior of bone materials.Homogenization methods have been introduced to provide a multiscale paradigm for analysis of poroelastic materials, and yield macroscopic balance laws that resemble the Biot's theory [1] while embedding microscopic features [2][3][4]. This work is motivated by the fact that as high-resolution digital imaging techniques emerge, such as the advancement of micro-CT and micro-magnetic resonance imaging (micro-MRI), the investigation of mechanical properties of cortical and trabecular bones can Multiscale Simulations and Mechanics of Biological Materials, First Edition. Edited by Shaofan Li and Dong Qian.

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Towards a multi‐scale computerized bone diagnostic system: 2D micro‐scale finite element analysis

Cited by 12 publications

References 29 publications

Multiscale FE method for analysis of bone micro-structures

Multiscale FE method for analysis of bone micro-structures

A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

Image‐Based Multiscale Modeling of Porous Bone Materials

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