Towards a More Precise Assay of Sperm Function in Egg Binding

Tanphaichitr, Nongnuj; Haebe, Jeff; Leader, Arthur; Carmona, Eurı́dice; Harris, Jeffrey D.; Silva, Solange Maria da; Antunes, Tayze T.; Chakrabandhu, Krittalak; Léveillé, Marie-Claude

doi:10.1016/s1701-2163(16)30308-5

Cited by 3 publications

(3 citation statements)

References 70 publications

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“…In this context, recent work by Tanphaichitr and colleagues suggest that the sulfoglycolipid sulfogalactosylglycerolipid (SGG) may also play a key role in gamete interaction [88 -95]. SGG (also known as seminolipid) is abundantly expressed in spermatozoa (constituting approximately 5-10 mol% of total sperm lipids depending on the species [94]). The saturated nature of its hydrocarbon chains (16:0/16:0), as well as strong intermolecular hydrogen-bonding networks, promotes the formation of ordered crystal-like SGG bilayers [96].…”

Section: Capacitationmentioning

confidence: 99%

New insights into the molecular mechanisms of sperm-egg interaction

Nixon

Aitken

McLaughlin

2007

Cell. Mol. Life Sci.

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At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell - the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion.

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Section: Capacitationmentioning

confidence: 99%

New insights into the molecular mechanisms of sperm-egg interaction

Nixon

Aitken

McLaughlin

2007

Cell. Mol. Life Sci.

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“…In particular, ZPC has been expressed in prokaryotic and eukaryotic systems (7)(8)(9)(10)(11)(12)(13)(14). Recombinant human ZP protein C (rec-hZPC) produced in Chinese hamster ovary (CHO) cells consistently has been shown to induce the acrosomal loss of human spermatozoa (7,8,15,16); in addition, rec-hZPC has been reported to bind to sperm components in solid-phase interaction assays (17,18).…”

mentioning

confidence: 99%

“…Sperm-ZP interaction assays have a high predictive value for IVF outcome (28), but they involve the use of a biologic material available in limited quantities. As an alternative, sperm could be challenged with rec-hZPC immobilized in a solid-phase support (17,29). Eventually, sperm selection based on their ability to interact with rec-hZPC could be used as a tool to improve fertilization rates in IVF procedures.…”

mentioning

confidence: 99%

Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm–zona pellucida interaction

Marı́n-Briggiler

González-Echeverría

Harris³

et al. 2008

Fertility and Sterility

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Human Exposure to Endocrine Disrupters and Semen Quality

Phillips

Tanphaichitr

2008

Journal of Toxicology and Environmental Health, Part B

166

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Reproductive pathology in the male represents about 20% of infertility cases. Male infertility may be attributed to a number of causes, including genetic and congenital abnormalities, infection, multisystemic diseases, varicocele, and others; however, a significant number of cases are idiopathic. Global declines in semen quality were suggested to be associated with enhanced exposure to environmental chemicals that act as endocrine disrupters as a result of our increased use of pesticides, plastics, and other anthropogenic materials. A significant body of toxicology data based upon laboratory and wildlife animals studies suggests that exposure to certain endocrine disrupters is associated with reproductive toxicity, including (1) abnormalities of the male reproductive tract (cryptorchidism, hypospadias), (2) reduced semen quality, and (3) impaired fertility in the adult. There is, however, a relative paucity of studies designed to measure exposure to endocrine disrupters on semen quality parameters (sperm concentration, motility, morphology). An overview of the human semen quality literature is presented that examines the role of endocrine disrupters including organochlorines (OC), dioxins, phthalates, phytoestrogens, and chemical mixtures (pesticides and tobacco smoke).

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Towards a More Precise Assay of Sperm Function in Egg Binding

Cited by 3 publications

References 70 publications

New insights into the molecular mechanisms of sperm-egg interaction

New insights into the molecular mechanisms of sperm-egg interaction

Recombinant human zona pellucida protein C produced in Chinese hamster ovary cells binds to human spermatozoa and inhibits sperm–zona pellucida interaction

Human Exposure to Endocrine Disrupters and Semen Quality

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