The quantification of the spatial and temporal variability of crop response to controllable inputs, and the relationship with their controlling factors is important for making input prescriptions. In this study we: (1) assessed the within‐field spatial variability of corn (Zea mays L.) response to nitrogen (NR) and seed (SR) rates using on‐farm precision experiments (OFPE) data and geographically weighted regression (GWR) models; (2) determined the spatial agreement between NR and SR response classes, and their temporal stability; and (3) modeled the effect of weather and site‐specific features on the spatial distribution of the responses. Response maps were estimated by fitting GWR models to yields and as‐applied NR and SR from 14 OFPE. Responses classified into positive and non‐positive response classes were spatially joined to weather, soil, and landscape covariates to train a random forest model. GWR models explained 30‐60% of yield variation. Positive responses to NR and SR represented about 46 and 33% of fields’ area, respectively, with large variation across field‐year combinations. Temporal agreement was about 50 – 60%, for NR and SR respectively. The spatial agreement between NR and SR response classes suggests that factors controlling the crop response to these inputs are similar. In both cases, weather variables were the most important predictors followed by landscape and soil attributes. Whereas weather variables acted at a field level, i.e., field‐year, the latter reflected the effect of within‐field variability on crop response. To reduce this weather uncertainty, future research should consider conducting larger numbers of OFPE across multiple seasons.This article is protected by copyright. All rights reserved