Towards a less invasive approach to the early goal-directed treatment of septic shock in the ED

Coen, Daniele; Cortellaro, Francesca; Pasini, Simone; Tombini, Valeria; Vaccaro, Angelica; Montalbetti, L.; Cazzaniga, Michela; Boghi, Daniele

doi:10.1016/j.ajem.2014.02.011

Cited by 37 publications

(27 citation statements)

References 47 publications

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“…The final revisions to the bundle are still in the approval process at the time of publication of this article. Alternative questions, such as how to guide elements of usual care [59], and alternative targets for hemodynamic resuscitation such as ultrasound evaluation of inferior vena cava filling [64], have been raised and may represent the future of sepsis research.…”

Section: Responses To New Trialsmentioning

confidence: 99%

Protocol-Based Management of Severe Sepsis and Septic Shock

Donovan

Shimabukuro

2015

Curr Anesthesiol Rep

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Sepsis remains a significant public health problem, with increasing incidence but decreasing mortality worldwide. The landmark Rivers study published in 2001 revolutionized the management of sepsis and septic shock, and brought early recognition, early antibiotic therapy, and protocol-based care to the forefront of sepsis management. However, certain components of the Rivers protocol have remained controversial and have not been widely accepted into practice. In addition, data for elements not included in the Rivers protocol have emerged. A series of three trials (ProCESS, ARISE, and ProMISe) designed with harmonized methods have recently demonstrated a lack of survival benefit for patients with septic shock treated with early goal directed therapy compared with usual care. Based on the results of these studies, the surviving sepsis campaign and national quality forum are revising their recommendations related to sepsis management.

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Section: Responses To New Trialsmentioning

confidence: 99%

Protocol-Based Management of Severe Sepsis and Septic Shock

Donovan

Shimabukuro

2015

Curr Anesthesiol Rep

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“…The incidence of severe sepsis and septic shock, as well as early mortality due to sepsis, has increased worldwide [1][2][3][4]. Although most patients with sepsis receive intensive management, such as early goaldirected therapy (EGDT), in an emergency department (ED), the mortality of sepsis has been reported to be greater than 20% to 30% [1,5].…”

Section: Introductionmentioning

confidence: 99%

Newly designed delta neutrophil index–to–serum albumin ratio prognosis of early mortality in severe sepsis

Hwang

Chung

Park

et al. 2015

The American Journal of Emergency Medicine

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“…We questioned how much fluid is given and which protocol was it based on, whether fluids were continued to be given to the patients who remained positive, and whether additional treatment was specified because in the study made by Coen et al [9], where central venous catheter was inserted to 61.7% of patients, none of the patient's CVPs were measured, and the fluid replacement method they had used to guide were not compared with CVP.…”

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confidence: 99%