Towards a dependable data set of structures for L-asparaginase research
Alexander Wlodawer,
Zbigniew Dauter,
Jacek Lubkowski
et al.
Abstract:The Protein Data Bank (PDB) includes a carefully curated treasury of experimentally derived structural data on biological macromolecules and their various complexes. Such information is fundamental for a multitude of projects that involve large-scale data mining and/or detailed evaluation of individual structures of importance to chemistry, biology and, most of all, to medicine, where it provides the foundation for structure-based drug discovery. However, despite extensive validation mechanisms, it is almost i… Show more
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