Towards a continuous flow environment for lipase-catalyzed reactions

Microfluidic multi-input reactor for biocatalytic synthesis using transketolase

“…By comparison with our single substrate input reactor we also see an increase in throughput from 3 mg h −1 to 15 mg h −1 . This clearly shows the improvements in throughput and space-time yield that are the foremost advantage of continuous flow reactors over batch or fed-batch reactors, which is in agreement with similar comparisons from the literature [34]. A continuous flow system is also of great interest for use in multi-step synthesis processes, where a cascade of separate reactors can be created to perform a complex conversion.…”

“…However these reactors cannot be operated in continuous-flow fashion, which limits their applicability for multi-step process integration. Additionally, the significant space-time-yield increases, characteristic of continuous-flow microreactors, cannot be exploited [34].…”

An efficient continuous flow process for the synthesis of a non-conventional mixture of fructooligosaccharides

“…However, even if the effectiveness of their combination has been recently demonstrated (Itabaiana, de Mariz e Miranda, & De Souza, 2013;Tamborini et al, 2012Tamborini et al, , 2013, the potential of biocatalysis in flow chemistry reactors is far from being fully exploited.…”

A Microfluidic Toolbox for the Development of In-Situ Product Removal Strategies in Biocatalysis

“…It is important to point out that the continuous-flow nature of microfluidics makes this technology suitable for development of continuous process concepts [38,54,55]. Continuous processes are recognized to give benefits such as reduced down-times, increased space-time yields, steadystate operation, improved heat, and mass transfer control, to name a few [56][57][58].…”