Toward understanding the signals of bacteriocin production by Streptococcus spp. and their importance in current applications

García-Curiel, Laura; López-Cuellar, Ma. del Rocío; Rodríguez-Hernández, Adriana-Inés; Chavarría-Hernández, Norberto

doi:10.1007/s11274-020-02973-5

Cited by 17 publications

(22 citation statements)

References 92 publications

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“…In this strain the genetic basis of bacteriocin production and regulation was further investigated. Bacteriocin production is often regulated through quorum sensing systems 40 . In streptococci , like S. intermedius and S. pyogenes the sil system controls bacteriocin production 12 , 17 .…”

Section: Discussionmentioning

confidence: 99%

Angicin, a novel bacteriocin of Streptococcus anginosus

Vogel

Bauer

Mauerer

et al. 2021

Sci Rep

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As a conserved defense mechanism, many bacteria produce antimicrobial peptides, called bacteriocins, which provide a colonization advantage in a multispecies environment. Here the first bacteriocin of Streptococcus anginosus, designated Angicin, is described. S. anginosus is commonly described as a commensal, however it also possesses a high pathogenic potential. Therefore, understanding factors contributing to its host colonization and persistence are important. A radial diffusion assay was used to identify S. anginosus BSU 1211 as a potent bacteriocin producer. By genetic mutagenesis the background of bacteriocin production and the bacteriocin gene itself were identified. Synthetic Angicin shows high activity against closely related streptococci, listeria and vancomycin resistant enterococci. It has a fast mechanism of action and causes a membrane disruption in target cells. Angicin, present in cell free supernatant, is insensitive to changes in temperature from − 70 to 90 °C and pH values from 2 to 10, suggesting that it represents an interesting compound for potential applications in food preservation or clinical settings.

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Section: Discussionmentioning

confidence: 99%

Angicin, a novel bacteriocin of Streptococcus anginosus

Vogel

Bauer

Mauerer

et al. 2021

Sci Rep

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“…In this strain the genetic basis of bacteriocin production and regulation was further investigated. Bacteriocin production is often regulated through quorum sensing systems 35 . In streptococci, like S. intermedius and S. pyogenes the sil system controls bacteriocin production 11,16 .…”

Section: Discussionmentioning

confidence: 99%

“…Bacteriocin production is often regulated through quorum sensing systems 35 . In streptococci, like S. intermedius and S. pyogenes the sil system controls bacteriocin production 11,16 .…”

Section: Discussionmentioning

confidence: 99%

Angicin, a novel bacteriocin of Streptococcus anginosus

Vogel

Bauer

Mauerer

et al. 2021

Preprint

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As a conserved defense mechanism, many bacteria produce antimicrobial peptides, called bacteriocins, which give a colonization advantage in a multispecies environment. Here the first bacteriocin of Streptococcus anginosus, designated Angicin, is described. S. anginosus is commonly described as a commensal, however it also possesses a high pathogenic potential. Therefore, understanding factors contributing to its host colonization and persistence are important. A radial diffusion assay was used to identify S. anginosus BSU 1211 as a potent bacteriocin producer. By genetic mutagenesis the background of bacteriocin production and the bacteriocin gene itself were identified. Synthetic Angicin shows high activity against closely related streptococci, listeria and vancomycin resistant enterococci. It has a fast mechanism of action and causes a membrane disruption in target cells. Angicin, present in cell free supernatant, is insensitive to changes in temperature from -70 to 90 °C and pH values from 2-10, suggesting that it represents an interesting compound for potential applications in food preservation or clinical settings.

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“…LAB produce bacteriocins by ribosomal synthesis, giving inactive molecules which become biologically active after chemical modifications [65]. Also, bacteriocins can be produced constitutively or by conditional systems (i.e., Quorum sensing) [66], which involves complex regulation systems (i.e., ComD/E, ComR/S) mediated by genes located in the LAB-chromosome in association with transposons and plasmids (i.e., genes encoding enterocins: entA, entB, entP, entQ, L50A). Moreover, it is common for LAB to produce more than one bacteriocin (Table 2) [67].…”

Section: Production Purification and Characterization Of Bacteriocinsmentioning

confidence: 99%

Bacteriocins Produced by LAB Isolated from Cheeses within the Period 2009–2021: a Review

Trejo-González

Gutiérrez-Carrillo

Rodríguez-Hernández

et al. 2021

Probiotics & Antimicro. Prot.

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A survey is presented concerning original research articles published in well-reputed scientific journals on the isolation of lactic acid bacteria (LAB) from cheeses worldwide, where researchers evaluated the bacteriocin production by such isolates in searching for novel functional peptides that can exhibit potential for biotechnological applications. Seventy-one articles were published in the period of study, with contributions being American (45%), Asiatic (28%), and European (21%), being Brazil-USA-Mexico, Turkey-China, and France-Italy the countries that contributed the most for each said continent, respectively. Most of the isolated LAB belong to the genera Enterococcus (35%), Lactobacillus (30%), Lactococcus (14%), and Pediococcus (10%), coming from soft (64%), hard (27%), and semi-hard (9%) cheeses, predominantly. Also, scholars focused mainly on the food biopreservation (81%) and pharmaceutical field (18%) potential applications.

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Toward understanding the signals of bacteriocin production by Streptococcus spp. and their importance in current applications

Cited by 17 publications

References 92 publications

Angicin, a novel bacteriocin of Streptococcus anginosus

Angicin, a novel bacteriocin of Streptococcus anginosus

Angicin, a novel bacteriocin of Streptococcus anginosus

Bacteriocins Produced by LAB Isolated from Cheeses within the Period 2009–2021: a Review

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