Toward the understanding of crystallization, mechanical properties and reactivity of multicomponent bioactive glasses

Pedone, Alfonso; Cannillo, Valeria; Menziani, Maria Cristina

doi:10.1016/j.actamat.2021.116977

Cited by 17 publications

(8 citation statements)

References 63 publications

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“…Such model mimicked the potential clinical application of the materials and employed human bone marrow mesenchymal stem cells. Furthermore, the reactivity and dissolution behaviour of such products was confirmed by means of a Molecular Dynamics model [21]. Thus, such bioactive glasses showed a very favourable combination of properties, i.e.…”

Section: Introductionmentioning

confidence: 84%

Spark plasma sintering, mechanical and in-vitro behavior of a novel Sr- and Mg-containing bioactive glass for biomedical applications

Angioni

Orrù

Cao

et al. 2022

Journal of the European Ceramic Society

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Section: Introductionmentioning

confidence: 84%

Spark plasma sintering, mechanical and in-vitro behavior of a novel Sr- and Mg-containing bioactive glass for biomedical applications

Angioni

Orrù

Cao

et al. 2022

Journal of the European Ceramic Society

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“…The reduced propensity of crystallization in the substituted glasses is due to increased chemical disorder around network former cations, the slower movement of alkaline earth cations compared to sodium, and the lower coordination number of magnesium, which impedes the significant structural reorganization necessary for the formation of the Na 2 Ca 2 Si 3 O 9 crystal phase. Silica network domination by fragmented chains is common to all compositions, and the network connectivity is alike 80 . Such studies provide a more profound comprehension of the relationship between structure and properties in bioactive glasses.…”

Section: Controlled Crystallizationmentioning

confidence: 97%

“…Silica network domination by fragmented chains is common to all compositions, and the network connectivity is alike. 80 Such studies provide a more profound comprehension of the relationship between structure and properties in bioactive glasses. It also offers valuable guidance for designing innovative bioactive glass compositions with specific properties and controlled crystallization for particular applications.…”

Section: Controlled Crystallizationmentioning

confidence: 99%

Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

Montazerian,

Shearer,

Mauro

2023

Int J Ceramic Engine & Sci

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Both unwanted and induced crystallization can impact bioactivity, physical and mechanical properties of bioactive glasses (BGs). Uncontrolled crystallization has negative consequences, rendering BGs unreliable. However, by manipulating the type, size, shape, and quantity of crystals in BGs, plenty of opportunities arise for controlling, for example, mechanical properties and degradability, leading to unique applications and improved performance. Understanding crystallization is a key step in developing bioactive glasses and glass‐ceramics (BGCs), and both fundamental and experimental research can aid in the design of BGCs for processing and biological function. In this perspective, we discuss the sources of crystallization and how controlled crystallization facilitates the functionalization of bioactive scaffolds, hybrids, coatings, composites, cements, and fibers.

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“…Recently, a lot of effort has been put to design alternative formulations, both to lower the tendency to crystallize and to increase the bioactivity with respect to the original 45S5 composition 15–17 . In particular, some specific ions (such as copper, zinc, silver, strontium, and magnesium) have shown favorable effects in terms of biological response, and have been therefore named as “therapeutic ions.” 17–20 …”

Section: Introductionmentioning

confidence: 99%

“…13,14 Recently, a lot of effort has been put to design alternative formulations, both to lower the tendency to crystallize and to increase the bioactivity with respect to the original 45S5 composition. [15][16][17] In particular, some specific ions (such as copper, zinc, silver, strontium, and magnesium) have shown favorable effects in terms of biological response, and have been therefore named as "therapeutic ions." [17][18][19][20] For example, magnesium is fundamental for bone metabolism, increases bone cell adhesion and stimulates new bone formation, 21 while strontium can be employed to stimulate osteogenesis and to reduce bone resorption in vivo, since it is able to stimulate osteoblasts and inhibit osteoclasts.…”

mentioning

confidence: 99%

In‐vivo evaluations of bone regenerative potential of two novel bioactive glasses

Anesi

Ferretti

Salvatori

et al. 2023

J Biomedical Materials Res

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Due to the aging of population, materials able to repair damaged tissues are needed. Among others, bioactive glasses (BGs) have attracted a lot of interest due to their outstanding properties both for hard and soft tissues. Here, for the first time, two new BGs, which gave very promising results in preliminary in vitro‐tests, were implanted in animals in order to evaluate their regenerative potential. The new BGs, named BGMS10 and Bio_MS and containing specific therapeutic ions, were produced in granules and implanted in rabbits' femurs for up to 60 days, to test their biocompatibility and osteoconduction. Additionally, granules of 45S5 Bioglass® were employed and used as a standard reference for comparison. The results showed that, after 30 days, the two novel BGs and 45S5 displayed a similar behavior, in terms of bone amount, thickness of new bone trabeculae and affinity index. On the contrary, after 60 days, 45S5 granules were mainly surrounded by wide and scattered bone trabeculae, separated by large amounts of soft tissue, while in BGMS10 and Bio_MS the trabeculae were thin and uniformly distributed around the BG granules. This latter scenario could be considered as more advantageous, since the features of the two novel BG granules allowed for the neo‐formation of a uniformly distributed bony trabeculae, predictive of more favorable mechanical behavior, compared to the less uniform coarse trabeculae, separated by large areas of soft tissue in 45S5 granules. Thus, BGMS10 and Bio_MS could be considered suitable products for tissue regeneration in the orthopedic and dental fields.

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Toward the understanding of crystallization, mechanical properties and reactivity of multicomponent bioactive glasses

Cited by 17 publications

References 63 publications

Spark plasma sintering, mechanical and in-vitro behavior of a novel Sr- and Mg-containing bioactive glass for biomedical applications

Spark plasma sintering, mechanical and in-vitro behavior of a novel Sr- and Mg-containing bioactive glass for biomedical applications

Perspectives on the impact of crystallization in bioactive glasses and glass‐ceramics

In‐vivo evaluations of bone regenerative potential of two novel bioactive glasses

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