Toward the Total Synthesis of Amphidinolide O: An Enantioselective Synthesis of C3-C8 Fragment. -Title fragment (X) is synthesized enantioselectively starting from L-(-)-malic acid (I) via 11 steps in 14 % overall yield. The diastereoselective Ireland-Claisen rearrangement of (VI) is used as a key step in order to implement the C4 and C5 chiral centers. -(HWANG, M.-H.; LEE*, D.-H.; Bull. Korean Chem.