Toward supramolecular nanozymes for the photocatalytic activation of Pt(iv) anticancer prodrugs

Abstract

Nanozymes based on TACN AuNPs and FMN photocatalyze the activation of a Pt(iv) prodrug into cisplatin.

Flavin-mediated photoactivation of Pt(iv) anticancer complexes: computational insights on the catalytic mechanism

“…4,5 Recently, we used flavin photocatalysis to devise novel strategies for the bioorthogonal catalytic activation of anticancer Pt(IV) complexes. [6][7][8][9][10][11] This is a class of metallodrugs that have been extensively developed in the last decades to overcome some of the drawbacks associated to the use of Pt(II) drugs (e.g. harsh side effects and resistance to treatment).…”

Enhancing the Photocatalytic Conversion of Pt(IV) Substrates by Flavoprotein Engineering

“…Besides providing one of the rare examples of catalytic reactions that use metal complexes as substrates, , this unconventional chemistry has interest in the design of new strategies for the (photo)­activation of metal-based prodrugs and their application in photochemotherapy. , …”

“…Besides providing one of the rare examples of catalytic reactions that use metal complexes as substrates, 5,6 this unconventional chemistry has interest in the design of new strategies for the (photo)activation of metal-based prodrugs and their application in photochemotherapy. 4,7 Considering the spectacular results obtained by protein engineering in catalysis, 8,9 we wondered how modification of flavoprotein structures could affect their capacity to catalytically transform Pt(IV) substrates and whether or not sitedirected mutagenesis could enhance their activation efficiency upon light irradiation. For this reason, we selected the FMNcontaining mSOG flavoprotein and investigated the catalytic performance of its Q103V, Q50E, and Q50W mutants with respect to the wild type (WT).…”

Unconventional Approaches in Coordination Chemistry and Organometallic Reactivity

“…Mazzei et al recently reported that this unconventional chemistry could be extended to the design of nanozymes. They developed a supramolecular photocatalyst by assembling FMN and Au nanoparticles decorated with a thiol bearing a 1,4,7-triazacyclononane headgroup and proved the photocatalytic conversion of a Pt­(IV) anticancer complex to cisplatin …”