Toward single breath‐hold whole‐heart coverage coronary MRA using highly accelerated parallel imaging with a 32‐channel MR system

Niendorf, Thoralf; Hardy, Christopher J.; Giaquinto, Randy O.; Gross, Patrick; Cline, H. E.; Zhu, Yangying; Kenwood, Gontran; Cohen, Shmuel; Grant, Aaron K.; Joshi, Sanjay; Rofsky, Neil M.; Sodickson, Daniel K.

doi:10.1002/mrm.20923

Cited by 118 publications

(85 citation statements)

References 35 publications

(41 reference statements)

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“…In addition to SNR gains and phase noise reduction at UHF (111)(112)(113), improvements are expected by using local multi-channel receive arrays for MR thermometry which demonstrated major SNR benefits over the use of the traditional RF body coil approach and are clinical routine (B0 ≤ 3.0T) (98,(114)(115)(116).…”

Section: Integrated Systems or Thermal Mrmentioning

confidence: 99%

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Winter

Oberacker

Paul

et al. 2015

International Journal of Hyperthermia

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Clinically established thermal therapies like thermo ablative approaches or adjuvant hyperthermia treatment rely on accurate thermal dose information for the evaluation and adaptation of the thermal therapy. Intratumoral temperature measurements have been correlated successfully with clinical endpoints. Magnetic resonance imaging is the most suitable technique for non-invasive thermometry avoiding complications related to invasive temperature measurements. Since the advent of MR thermometry two decades ago, numerous MR thermometry techniques have been developed continuously increasing accuracy and robustness for in vivo applications. While this progress was primarily focused on relative temperature mapping, current and future efforts will likely close the gap towards quantitative temperature readings. These efforts are essential to benchmark thermal therapy efficiency, understand temperature related biophysical and physiological processes and to use these insights to set new landmarks for diagnostic and therapeutic applications. With that in mind, this review summarizes and discusses advances in MR thermometry providing practical considerations, pitfalls and technical obstacles constraining temperature measurement accuracy, spatial and temporal resolution in vivo. Established approaches and current trends in thermal therapy hardware are surveyed with respect to potential benefits for MR thermometry.3

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Section: Integrated Systems or Thermal Mrmentioning

confidence: 99%

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Winter

Oberacker

Paul

et al. 2015

International Journal of Hyperthermia

Self Cite

185

165

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“…[38][39][40] Finally, higher field strengths, such as 3.0 T imaging systems, offer the potential for further improvement in SNR, spatial resolution, 41 and imaging speed. 42,43 Further investigations are necessary to evaluate the possible benefits of these methods in a patient population.An alternative approach to minimally invasive coronary artery imaging is multislice computed tomography, which has been practically used. 22 The state-of-the-art 64-slice computed tomography has shown very high diagnostic accuracy and image quality.…”

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confidence: 99%

Three-Dimensional Breathhold Magnetization-Prepared TrueFISP

McCarthy¹,

Deshpande²,

Beohar³

et al. 2007

Investigative Radiology

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Purpose-X-ray angiography is currently the standard test for the assessment of coronary artery disease. A substantial minority of patients referred for coronary angiography have no significant coronary artery disease. The purpose of this work was the evaluation of the accuracy of a threedimensional (3D) breathhold coronary magnetic resonance angiography (MRA) technique in detecting hemodynamically significant coronary artery stenoses in a patient population with x-ray angiographic correlation.Materials and Methods-Sequential subjects (n = 33, M/F = 22/11, average age = 57) who were referred for conventional coronary angiography were enrolled in the study. The study protocol was approved by our institutional review board. Each subject gave written informed consent. Volume-targeted 3D breathhold coronary artery scans with ECG-triggered, segmented True Fast Imaging with Steady-state Precession (TrueFISP) were acquired for the left main (LM), left anterior descending (LAD), and right coronary arteries (RCAs). Coronary MRA was evaluated with conventional angiography as the gold standard.Results-The overall sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing any hemodynamically significant coronary artery disease (≥50% diameter reduction) with coronary MRA was 87%, 57%, 72%, 68%, and 80%, respectively. The sensitivity of the technique in the LM, LAD, and RCA was 100%, 83%, and 100%, respectively. The NPV of the technique in the LM, LAD, and RCA was 100%, 82%, and 100%, respectively. Magnetic resonance imaging (MRI) has recently gained wide acceptance in cardiovascular disease examinations. Substantial progress has been made in developing MRI techniques for imaging coronary arteries in the past 10 years. These techniques can be divided into 2 major approaches based on the methods used for reducing respiration-related motion effects: freebreathing techniques with navigator echo-guided slice correction and breathhold techniques. Encouraging results have been shown using the free-breathing approach to detect significant coronary artery disease. [3][4][5] One of the shortcomings of the free-breathing approach is the relatively long imaging time per scan. Suboptimal image quality may result if heartbeat or breathing pattern changes substantially during data acquisition. Conclusions-Three-dimensionalWith the improved gradient system in recent MRI scanners, it is now possible to obtain three-dimensional (3D) images within a single breathhold. 6 However, with the conventional gradient-echo sequence Fast Low Angle Shot (FLASH), the signal-to-noise ratio (SNR) and spatial resolution are limited because of the constraint of the imaging time. 7 Administration of MR contrast media has substantially improved the SNR and contrast-to-noise ratio (CNR) of coronary arteries. [8][9][10][11][12] However, the number of contrast-enhanced breathhold scans in an imaging session was limited by the total contrast volume allowed per subject. Potential errors in time dela...

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“…However, highly accelerated studies on our 32-channel system using three-dimensional imaging sequences without injected contrast agents have also yielded high-quality images, for example for coronary artery imaging (23,24), brain imaging (25), or abdominal screening (26). This is in part because three-dimensional imaging sequences in general also offer a particular synergy with parallel imaging, not only because of the availability of multiple directions suitable for acceleration, but also because SNR in these sequences increases with the quantity of acquired data.…”

Section: Discussionmentioning

confidence: 99%

Rapid Volumetric MRI Using Parallel Imaging With Order-of-Magnitude Accelerations and a 32-Element RF Coil Array

et al. 2005

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Rationale and Objectives-Many clinical applications of Magnetic Resonance Imaging are constrained by basic limits on imaging speed. Parallel MRI relaxes these limits by using the sensitivity patterns of arrays of radiofrequency receiver coils to encode spatial information in a manner complementary to traditional encoding with magnetic field gradients. Until now, parallel MRI has been used to achieve modest improvements in imaging speed; order-of-magnitude improvements have been elusive given fundamental losses in signal-to-noise ratio. The goal of this work was to demonstrate that, with appropriate hardware and careful SNR management, rapid volumetric imaging at high accelerations is in fact feasible.Materials and Methods-Contrast-enhanced MRI with an axial 3D spoiled gradient echo imaging sequence was performed in healthy adult subjects using a 32-element RF coil array and a prototype 32-channel MR imaging system. Large imaging volumes were prescribed, in place of traditional limited slabs targeted only to suspect regions.Results-As much as 16-fold net accelerations of imaging were achieved repeatably using this approach. The use of large 3D volumes allowed comprehensive anatomical coverage at clinically useful spatial and/or temporal resolution. The need for careful, time-consuming, and subject-specific scan prescription was also eliminated. Conclusion-The highly parallel imaging approach presented here allows previously inaccessible volumetric coverage for time-sensitive MRI examinations such as contrast-enhanced MRA, and simultaneously provides a substantially simplified imaging paradigm. The resulting capability for rapid volumetric imaging promises to combine the strengths of MRI with some of the advantages of alternative imaging modalities such as multidetector CT.

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Toward single breath‐hold whole‐heart coverage coronary MRA using highly accelerated parallel imaging with a 32‐channel MR system

Cited by 118 publications

References 35 publications

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Magnetic resonance thermometry: Methodology, pitfalls and practical solutions

Three-Dimensional Breathhold Magnetization-Prepared TrueFISP

Rapid Volumetric MRI Using Parallel Imaging With Order-of-Magnitude Accelerations and a 32-Element RF Coil Array

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