Toward Point-of-Care chronic disease Management: Biomarker detection in exhaled breath using an E-Nose sensor based on rGO/SnO2 superstructures

Shanmugasundaram, Arunkumar; Manorama, Sunkara V.; Kim, Dong–Su; Jeong, Yun-Jin; Lee, Dong Weon

doi:10.1016/j.cej.2022.137736

Cited by 38 publications

(21 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When a sensor is exposed to an analyte gas, dissociated gas may preferentially and strongly adsorb at reduced graphene oxide-SnO 2 nanospheres interfaces because these interfaces have high active sites such as vacancies, line defects, and strong electronic interaction between graphene and metal oxides. Under these conditions, the reduced graphene oxide nanosheets acting as electron transporters will accept electrons from the adjacent SnO 2 nanospheres, hence enhancing the sensing response of the sensor [17]. The proposed reduced graphene oxide-SnO 2 nanospheres sensor showed significantly better or comparable sensing performance compared to the reported heptane and decane sensors as shown in Table 1.…”

Section: Resultsmentioning

confidence: 87%

SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer

Shanmugasundaram

Lee

2022

Micro and Nano Syst Lett

Self Cite

View full text Add to dashboard Cite

Metal oxide-based sensors have been widely used to detection biomarkers in exhaled breath for identification of various diseases such as asthma, diabetes, halitosis, and lung cancer. Herein, we proposed one step hydrothermal method for the preparation of SnO2 nanospheres and reduced graphene oxide incorporated SnO2 nanospheres for the detection of two important biomarkers such as decane and heptane from the exhaled breath of lung cancer patients. The as prepared materials are investigated in detail through various analytical techniques and the findings are consistent with each other. The sensing response of the proposed sensors were systematically investigated to enhance their sensing performance as a function of operating temperatures and gas concentration, and different analyte gases. The sensors showed maximum sensing response toward heptane and decane compared to other interfering gases such as hydrogen, carbon monoxide, acetone, ethanol, and methanol at 125 °C. The proposed sensors exhibit excellent detection range as low as 1 ppm with appreciably fast response and recovery time. Lung cancer patients may be easily screened using the proposed sensor, by detecting decane and heptane in their exhaled breath.

show abstract

Section: Resultsmentioning

confidence: 87%

SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer

Shanmugasundaram

Lee

2022

Micro and Nano Syst Lett

Self Cite

View full text Add to dashboard Cite

show abstract

“…Formaldehyde is a common toxic carcinogen in the environment and an important biomarker for LC [34,99]. LC patients have been shown to convert active aldehydes into stable oximes by means of on-fiberderivatization (SPME-OFD) [100].…”

Section: Formaldehydementioning

confidence: 99%

“…Pretreatment processes such as dehumidification and filter are significant to improve the accuracy of breath diagnosis when the resistance property of metal oxide materials cannot meet the requirement. An ideal respiratory gas sensor should have excellent selectivity, moisture Biomarker n-propanol [28] Toluene [29] Isoprene [30,31] Cyclohexane [28] Acetaldehyde [32] Formaldehyde [33,34] resistance, ppb-level detection limit, and high sensitivity. Therefore, it is urgent to develop gas sensing materials with excellent performance to meet the requirements of LC respiratory diagnosis.…”

Section: Introduction mentioning

confidence: 99%

Metal oxide semiconductor gas sensing materials for early lung cancer diagnosis

He¹,

Chai²,

Luo³

et al. 2023

Journal of Advanced Ceramics

View full text Add to dashboard Cite

The urgency of early lung cancer (LC) diagnosis and treatment has been more and more significant. Exhaled breath analysis using gas sensors is a promising way to find out if someone has LC due to its low-cost, non-invasive, and real-time monitoring compared with traditional invasive diagnostic techniques. Among sensor-based gas detection techniques, metal oxide semiconductor's gas sensors are one of the most important types. This review presents the-state-of-art in metal oxide gas sensors for the diagnosis of early LC. First, the exhaled breath biomarkers are described with emphasis on the concentration of abnormal volatile organic compounds (VOCs) caused by the metabolic process of LC cells. Then, the research status of metal oxide gas sensors in LC diagnosis is summarized. The sensing performance and enhancement strategy of biomarkers provided by metal oxide semiconductor materials are reviewed. Another effective way to improve VOC detection performance is to build a gas sensor array. At the same time, various gas sensors combined with self-powered techniques are mentioned to display a broad development prospect in breath diagnosis.Finally, metal oxide gas sensor-based LC diagnosis is prospected.

show abstract

“…Even if the association between a particular illness and certain VOCs has been recognized for more than a century, only current technologies based on semiconductor gas sensors can provide the quantitative measurements required for stringent clinical practice. Clinical experiments have shown the potential for utilizing breath to diagnose major diseases, including many forms of cancer, diabetes, multiple sclerosis, and kidney disease [ 181 ]. The invention and widespread use of solid-state gas sensors have offered an additional boost to the interest in VOC inspection and analysis for medical applications [ 182 ].…”

Section: Potential Biomedical Applicationmentioning

confidence: 99%

Semiconductor Multimaterial Optical Fibers for Biomedical Applications

et al. 2022

View full text Add to dashboard Cite

Integrated sensors and transmitters of a wide variety of human physiological indicators have recently emerged in the form of multimaterial optical fibers. The methods utilized in the manufacture of optical fibers facilitate the use of a wide range of functional elements in microscale optical fibers with an extensive variety of structures. This article presents an overview and review of semiconductor multimaterial optical fibers, their fabrication and postprocessing techniques, different geometries, and integration in devices that can be further utilized in biomedical applications. Semiconductor optical fiber sensors and fiber lasers for body temperature regulation, in vivo detection, volatile organic compound detection, and medical surgery will be discussed.

show abstract

Toward Point-of-Care chronic disease Management: Biomarker detection in exhaled breath using an E-Nose sensor based on rGO/SnO2 superstructures

Cited by 38 publications

References 75 publications

SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer

SnO2/rGO nanocomposite for the detection of biomarkers of lung cancer

Metal oxide semiconductor gas sensing materials for early lung cancer diagnosis

Semiconductor Multimaterial Optical Fibers for Biomedical Applications

Contact Info

Product

Resources

About