Toward Online Adaptive Hyperthermia Treatment Planning: Correlation Between Measured and Simulated Specific Absorption Rate Changes Caused by Phase Steering in Patients

Kok, H. Petra; Ciampa, S.; Kroon-Oldenhof, Rianne de; Steggerda-Carvalho, Eva J.; Stam, Gerard van; Vörding, Paul J. Zum Vörde Sive; Stalpers, Lukas J.A.; Geijsen, Elisabeth D.; Bardati, F.; Bel, Arjan; Crezee, J.

doi:10.1016/j.ijrobp.2014.05.1307

Cited by 44 publications

(39 citation statements)

References 28 publications

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“…Treatment settings optimized in pretreatment planning could still produce treatment limiting hotspots [94]; strategies are therefore under development to quantify objective or subjective feedback to the treatment planning system for real-time adaptation recalculation of the treatment settings [85]. In this approach, information such as temperature readings from invasive, intraluminal [85,94,95] or non-invasive temperature measurements [90,96,97] and subjective information such as complaints from the patient are combined and used as feedback to derive improved settings [98]. Subsequently, treatment settings are adjusted in real-time to reduce hotspots while retaining or increasing target temperatures by increasing the applied power [99].…”

Section: Simulation-guided Adaptive Hyperthermia Techniquesmentioning

confidence: 99%

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Datta

Ordóñez

Gaipl

et al. 2015

Cancer Treatment Reviews

445

393

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Section: Simulation-guided Adaptive Hyperthermia Techniquesmentioning

confidence: 99%

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Datta

Ordóñez

Gaipl

et al. 2015

Cancer Treatment Reviews

445

393

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“…An advantage of hyperthermia is that the thermal dose delivered is regularly measured during the 1-h treatment using temperature probes or with non-invasive MR thermometry. This permits online re-planning yielding adapted settings correcting the thermal dose distribution during the session itself [65][66][67][68]. It also permits retrospective reconstruction of the given thermal dose distribution during each session, followed by re-planning the optimal thermal dose distribution for the remaining sessions based on the cumulative dose already given.…”

Section: Further Researchmentioning

confidence: 99%

Thermoradiotherapy planning: Integration in routine clinical practice

Crezee

Leeuwen

Oei

et al. 2015

International Journal of Hyperthermia

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Planning of combined radiotherapy and hyperthermia treatments should be performed taking the synergistic action between the two modalities into account. This work evaluates the available experimental data on cytotoxicity of combined radiotherapy and hyperthermia treatment and the requirements for integration of hyperthermia and radiotherapy treatment planning into a single planning platform. The underlying synergistic mechanisms of hyperthermia include inhibiting DNA repair, selective killing of radioresistant hypoxic tumour tissue and increased radiosensitivity by enhanced tissue perfusion. Each of these mechanisms displays different dose-effect relations, different optimal time intervals and different optimal sequences between radiotherapy and hyperthermia. Radiosensitisation can be modelled using the linear-quadratic (LQ) model to account for DNA repair inhibition by hyperthermia. In a recent study, an LQ model-based thermoradiotherapy planning (TRTP) system was used to demonstrate that dose escalation by hyperthermia is equivalent to $10 Gy for prostate cancer patients treated with radiotherapy. The first step for more reliable TRTP is further expansion of the data set of LQ parameters for normally oxygenated normal and tumour tissue valid over the temperature range used clinically and for the relevant time intervals between radiotherapy and hyperthermia. The next step is to model the effect of hyperthermia in hypoxic tumour cells including the physiological response to hyperthermia and the resulting reoxygenation. Thermoradiotherapy planning is feasible and a necessity for an optimal clinical application of hyperthermia combined with radiotherapy in individual patients.

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“…Final settings are validated by performing ΔT pulses for three phase settings with 40° phase shifts between the dorsal and ventral antenna [26]. …”

Section: Introductionmentioning

confidence: 99%

A systematic review of regional hyperthermia therapy in bladder cancer

Longo

Gopalakrishna

Tsivian

et al. 2016

International Journal of Hyperthermia

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Context Bladder cancer therapy remains suboptimal as the morbidity and mortality remains high amongst those with non-muscle invasive and muscle-invasive disease. Regional hyperthermia therapy (RHT) is a promising adjunctive therapy being tested in multiple clinical contexts. Objective To systematically review the literature on the efficacy and toxicity of RHT. Evidence Acquisition The systematic review was registered with the PROSPERO database (Registration number: CRD42015025780) and was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently and a third reviewer arbitrated disagreements. The last search was performed on August 28, 2015. A descriptive analysis was performed and quality assessment was conducted using the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Cochrane Risk of Bias Assessment Tool for trials. Evidence Synthesis We identified 859 publications in the initial search, of which 24 met inclusion criteria for full-text review. Of these, we were able to obtain data on the outcomes of interest for 15 publications. Conclusions The review underscores the limited nature of the evidence; definitive conclusions are elusive. However, the promising results of RHT in the setting of intravesical chemotherapy, chemotherapy and radiotherapy show a trend towards legitimate efficacy.

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Toward Online Adaptive Hyperthermia Treatment Planning: Correlation Between Measured and Simulated Specific Absorption Rate Changes Caused by Phase Steering in Patients

Cited by 44 publications

References 28 publications

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future

Thermoradiotherapy planning: Integration in routine clinical practice

A systematic review of regional hyperthermia therapy in bladder cancer

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