Toward next-generation primate neuroscience: A collaboration-based strategic plan for integrative neuroimaging

The Brain/MINDS Marmoset Connectivity Atlas: exploring bidirectional tracing and tractography in the same stereotaxic space

“…The importance of non-human primates for the translation of biological findings to human health applications has been repeatedly emphasized ( Wang et al, 2020 ; Milham et al, 2022 ). Indeed, primate models like the marmoset have gained popularity because of their similarity in brain structure with the human brain, and cognitive abilities, which allow for informed analysis of various brainrelated diseases such as autism, schizophrenia, or dementia.…”

“…development of the BMCA is part of the international trend towards open-access resources for the exploration of brain connectivity. Integration of connectivity datasets into multimodal platforms has recently been identified as a priority area for the advancement of translational neuroscience(Milham et al, 2022), and the present resource addresses this need. In this regard, the BMCA extends and complements capabilities offered by other online resources.…”

Resting-state fMRI-based screening of deschloroclozapine in rhesus macaques predicts dosage-dependent behavioral effects

“…Thus, rs-fMRI has advantages for screening chemogenetic actuators in naive animals without specific task training. Moreover, rs-fMRI is potentially useful for “benchmarking” the selectivity and potency of novel chemogenetic actuators [47], accelerating the development of chemogenetics in primates.…”

An integrated resource for functional and structural connectivity of the marmoset brain

“…Second, most rs-fMRI datasets were acquired from anesthetized animals, resulting in difficulties for crossspecies studies, particularly relative to awake human brains (Hudetz, 2012). The final barrier is the practical difficulty of training animals to be fully awake during MRI scans (Milham et al, 2021;Milham et al, 2020). Given that, a platform for international collaborative research (PRIMatE RESOURCE EXCHANGE) was initiated to promote open resource exchange and standards for NHP neuroimaging (Messinger et al, 2021;Milham et al, 2018).…”

“…To address these challenges and limitations, in complete alignment with a strategic plan developed by the NHP imaging community (Milham et al, 2021), we developed standardized awake imaging protocols for marmosets, acquiring the most sizeable to date open-access datasets of awake rs-fMRI across two institutions, the National Institutes of Health (NIH), USA, and the Institute of Neuroscience (ION), China. Furthermore, we also integrated neuronal-tracing and different diffusion MRI datasets into the same MRI space, resulting in the comprehensive resource, which allows exploration of the relationships between structural and functional connectome.…”