Toward neuromarkers for tailored smoking cessation treatments

Individual differences in late positive potential amplitude and theta power predict cue-induced eating

“…Inherent differences between humans and animal models [ 58 ], especially when executive control and higher cognitive functions are central for the execution of a task [ 11 ], make direct comparisons of human and animal results difficult. Further studies leveraging the paradigm that we used here should facilitate the bidirectional translation and improvement of both animal models and human research investigating cue-induced behavior [ 31 , 64 ]. while the validity of the LPP as a predictor of cue-induced behaviors has been well replicated [ 33 , 56 , 65 , 66 ] and is consistent with theoretical models concerning the motivational salience of cues [ 12 , 44 ], the predictive validity of the theta-based correlate as described in the present study is novel and should be considered preliminary until replicated.…”

“…Typically, highly salient images such as erotica and mutilations prompt larger LPP responses compared to images with lower salience, such as romantic or sad images [ 21 – 25 ]. Prior research also showed that the affective modulation of the LPP has high internal and test-retest reliability [ 26 – 28 , 23 ] and is robust to manipulations of the images’ perceptual characteristics [ 29 , 30 ], making it an excellent tool to assess how individual differences in affective reactivity might influence behaviors [ 25 , 31 ]. By applying cluster analysis, a multivariate classification technique [ 32 ], to the LPP responses evoked by the range of stimuli presented during the cued food delivery task, we identified two reactivity profiles associated with individual differences in the tendency to attribute motivational salience to reward-related cues.…”