Toward Neuro-Oncologic Clinical Trials of High-Dose-Rate Synchrotron Microbeam Radiation Therapy: First Treatment of a Spontaneous Canine Brain Tumor

Adam, J.F.; Balosso, Jacques; Bayat, Sam; Berkvens, P.; Berruyer, G.; Bräuer-Krisch, Elke; Brochard, T.; Chamel, Gabriel; Desagneaux, A.; Drevon-Gaud, R.; Eling, Laura; Estève, François; Flandin, I.; Gaudin, M; Giraud, Jean-Yves; Giraud, L.; Gonzalez, Hervé; Kefs, Samy; KESHMIRI, Sarvenaz; Krainik, Alexandre; Krisch, M.; Laissue, Jean A.; Lemaire, G.; Mauro, Anthony; Némoz, Christian; Pellicioli, Paolo; Renier, M.; Verry, Camille; Serduc, Raphaël

doi:10.1016/j.ijrobp.2022.04.022

Cited by 20 publications

(15 citation statements)

References 21 publications

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“…The importance to study the effects of high dose rate radiotherapy in veterinary patients before proposing human clinical trials has been recognized because dogs, for instance, suffer from spontaneous tumors which are very similar in size, histology, and natural course of the disease, compared to human patients [ 45 , 46 ]. The first successful veterinary studies were and are conducted with FLASH radiotherapy [ 21 , 22 ] and with MRT, the latter focused on the treatment of dogs with malignant brain tumors [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research

Schültke

Fiedler²,

Mewes³

et al. 2022

Cancers

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High dose rate radiotherapies such as FLASH and microbeam radiotherapy (MRT) both have developed to the stage of first veterinary studies within the last decade. With the development of a new research tool for high dose rate radiotherapy at the end station P61A of the synchrotron beamline P61 on the DESY campus in Hamburg, we increased the research capacity in this field to speed up the translation of the radiotherapy techniques which are still experimental, from bench to bedside. At P61, dose rates of several hundred Gy/s can be delivered. Compared to dedicated biomedical beamlines, the beam width available for MRT experiments is a very restrictive factor. We developed two model systems specifically to suit these specific technical parameters and tested them in a first set of experiments.

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Section: Discussionmentioning

confidence: 99%

“…It has been shown in small animal models that MRT, alone or in combination with a course of conventional radiotherapy, can control malignant tumors much better than conventional irradiation alone [ 18 , 19 , 20 ]. The first veterinary patient with a malignant brain tumor was successfully treated with MRT in September 2021 [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research

Schültke

Fiedler²,

Mewes³

et al. 2022

Cancers

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“…FLASH radiotherapy with electrons at a modified clinical LINAC and the monoplanar MBI at the synchrotron have both already advanced to the stage of veterinary studies [ 36 , 37 , 38 ]. It remains questionable whether the timely sequence of the conventional irradiation and high dose rate radiotherapy boost is of any consequence.…”

Section: Discussionmentioning

confidence: 99%

Good Timing Matters: The Spatially Fractionated High Dose Rate Boost Should Come First

Schültke

Jaekel

Bartzsch

et al. 2022

Cancers

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Monoplanar microbeam irradiation (MBI) and pencilbeam irradiation (PBI) are two new concepts of high dose rate radiotherapy, combined with spatial dose fractionation at the micrometre range. In a small animal model, we have explored the concept of integrating MBI or PBI as a simultaneously integrated boost (SIB), either at the beginning or at the end of a conventional, low-dose rate schedule of 5x4 Gy broad beam (BB) whole brain radiotherapy (WBRT). MBI was administered as array of 50 µm wide, quasi-parallel microbeams. For PBI, the target was covered with an array of 50 µm × 50 µm pencilbeams. In both techniques, the centre-to-centre distance was 400 µm. To assure that the entire brain received a dose of at least 4 Gy in all irradiated animals, the peak doses were calculated based on the daily BB fraction to approximate the valley dose. The results of our study have shown that the sequence of the BB irradiation fractions and the microbeam SIB is important to limit the risk of acute adverse effects, including epileptic seizures and death. The microbeam SIB should be integrated early rather than late in the irradiation schedule.

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“…Novel and recent concepts [113,114] offer promise of enabling the MRT exploration outside synchrotrons sources, although MRT would still be limited to low energy X-rays beams [115]. The first MRT in trial has been recently performed in dogs [116]. The results of the short follow up (3 months) in treated dogs are promising, however, insufficient for solid conclusions yet.…”

Section: Tablementioning

confidence: 99%

Novel unconventional radiotherapy techniques: Current status and future perspectives – Report from the 2nd international radiation oncology online seminar

Tubin

M.C.

Prezado

et al. 2023

Clinical and Translational Radiation Oncology

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Toward Neuro-Oncologic Clinical Trials of High-Dose-Rate Synchrotron Microbeam Radiation Therapy: First Treatment of a Spontaneous Canine Brain Tumor

Cited by 20 publications

References 21 publications

The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research

The Microbeam Insert at the White Beam Beamline P61A at the Synchrotron PETRA III/DESY: A New Tool for High Dose Rate Irradiation Research

Good Timing Matters: The Spatially Fractionated High Dose Rate Boost Should Come First

Novel unconventional radiotherapy techniques: Current status and future perspectives – Report from the 2nd international radiation oncology online seminar

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