Toward Modular Chemistry with the Dendritic Box as Module

Abstract

ABSTRACT. In this paper we like to present the dendritic box as a new tool toward modular chemistry. A dendritic structure with a densely-packed shell is prepared via modification o f the fifth generation poly(propylene imine) dendrimers with N-BOC-L-phenylalanine groups. This so-called dendritic box has a diameter of approximately 4.5 nm, as determined by DLS and SAXS, and has internal cavities which can be used for the encapsulation o f guest molecules.

Evaluation of Multivalent Dendrimers Based on Melamine: Kinetics of Thiol−Disulfide Exchange Depends on the Structure of the Dendrimer

“…A number of observations suggested that the cooperative pathway described by Scheme might be accessible. First, there are many reports of sequestration of hydrophobic molecules by dendrimers. − Most notable is Meijer's “dendritic box” which sequesters hydrophobic guests as a function of the peripheral group. − Such sequestration in our system could lead to cooperative release of ligands from the dendrimer. Second, intramolecular thiol−disulfide exchange to form large macrocycles has been reported. − Notably, Rabenstein has observed that the single disulfide of somatostatin (RSSR),which has undergone thiol−disulfide exchange with glutathione (GSH) to yield the mixed thiol−disulfide, reacts intramolecularly to form a 38-atom macrocycle faster than intermolercularly with a second equivalent of glutathione .…”