Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

Tobin, Nicolas; Manning, Keefe B.

doi:10.1002/cnm.3638

Cited by 5 publications

(3 citation statements)

References 41 publications

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“…This causes the absence of leaflet motion, predisposing to clot formation. The surgical procedure as it stands causes significant endothelial damage to the vessel walls, which can contribute both to the issues obtaining hemostasis, as well as clot formation after hemostasis has occurred [ 18 ]. Graft thrombosis could potentially be addressed in several ways.…”

Section: Discussionmentioning

confidence: 99%

Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models

Skidmore

Hill

Bishara

et al. 2023

JCDD

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Unrepairable congenital heart valve disease is an unsolved problem in pediatric cardiac surgery because there are no growing heart valve implants. Partial heart transplantation is a new type of transplant that aims to solve this problem. In order to study the unique transplant biology of partial heart transplantation, animal models are necessary. This study aimed to assess the morbidity and mortality of heterotopic partial heart transplantation in rodent models. This study assessed two models. The first model involved transplanting heart valves from donor animals into the abdominal aortic position in the recipient animals. The second model involved transplanting heart valve leaflets into the renal subcapsular position of the recipient animals. A total of 33 animals underwent heterotopic partial heart transplantation in the abdominal aortic position. The results of this model found a 60.61% (n = 20/33) intraoperative mortality rate and a 39.39% (n = 13/33) perioperative mortality rate. Intraoperative mortality was due to vascular complications from the procedure, and perioperative mortality was due to graft thrombosis. A total of 33 animals underwent heterotopic partial heart transplantation in the renal subcapsular position. The results of this model found a 3.03% (n = 1/33) intraoperative mortality rate, and the remaining 96.97% survived (n = 32/33). We conclude that the renal subcapsular model has a lower mortality rate and is technically more accessible than the abdominal aortic model. While the heterotopic transplantation of valves into the abdominal aortic position had significant morbidity and mortality in the rodent model, the renal subcapsular model provided evidence for successful heterotopic transplantation.

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Section: Discussionmentioning

confidence: 99%

Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models

Skidmore

Hill

Bishara

et al. 2023

JCDD

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“… 5 were made by Yang et al . 6 and Tobin and Manning 7 . Apart from modeling clot mechanics, CFD has even been shown useful in predicting regions of clot-formation in vivo 8 , 9 and being applied to predict thrombosis is specific disease states 10 and medical devices 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Despite the long history and relative success of computationally modeling clot formation and lysis, there have been fewer attempts at modeling embolization. Tobin and Manning 7 investigated thrombosis and thromboembolism in turbulent flows. By incorporating the viscoelastic modeling of Fogelson and Guy 4 , they were able to produce instances of embolization in the backward-facing step used by Taylor et al .…”

Section: Introductionmentioning

confidence: 99%

Clot embolization studies and computational framework for embolization in a canonical tube model

Tobin,

Li,

Hiller

et al. 2023

Sci Rep

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Despite recent advances in the development of computational methods of modeling thrombosis, relatively little effort has been made in developing methods of modeling blood clot embolization. Such a model would provide substantially greater understanding of the mechanics of embolization, as in-vitro and in-vivo characterization of embolization is difficult. Here, a method of computationally simulating embolization is developed. Experiments are performed of blood clots formed in a polycarbonate tube, where phosphate-buffered saline is run through the tube at increasing flow rates until the clot embolizes. The experiments revealed embolization can be initiated by leading edge and trailing edge detachment or by non-uniform detachment. Stress-relaxation experiments are also performed to establish values of constitutive parameters for subsequent simulations. The embolization in the tube is reproduced in silico using a multiphase volume-of-fluid approach, where the clot is modeled as viscoelastic. By varying the constitutive parameters at the wall, embolization can be reproduced in-silico at varying flow rates, and a range of constitutive parameters fitting the experiments is reported. Here, the leading edge embolization is simulated at flow rates consistent with the experiments demonstrating excellent agreement in this specific behavior.

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A Numerical Simulation of Reciprocating Blood Pump: Effect of Valve Movement and Leakage Flow on Hemolytic Performance

Vakilzadeh,

Bagheri Sarvestani,

Kamali

et al. 2024

Iran J Sci Technol Trans Mech Eng

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Toward modeling thrombosis and thromboembolism in laminar and turbulent flow regimes

Cited by 5 publications

References 41 publications

Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models

Morbidity and Mortality of Heterotopic Partial Heart Transplantation in Rodent Models

Clot embolization studies and computational framework for embolization in a canonical tube model

A Numerical Simulation of Reciprocating Blood Pump: Effect of Valve Movement and Leakage Flow on Hemolytic Performance

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