Toward Metal Complexes That Can Directionally Walk Along Tracks: Controlled Stepping of a Molecular Biped with a Palladium(II) Foot

Beves, Jonathon E.; Blanco, Víctor Francisco Sampedro; Blight, Barry A.; Carrillo, Romen; D’Souza, Daniel M.; Howgego, David; Leigh, David A.; Slawin, Alexandra M. Z.; Symes, Mark D.

doi:10.1021/ja4123973

Cited by 49 publications

(46 citation statements)

References 82 publications

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“…To date, Pt(II) migration has only been observed over a single bipedal transfer 54,62,63 . A related system utilizing Pd(II) with a track of pyridine ligands alternatively required addition of heat and a pH change to drive bipedal walking 64 . Neither metal will likely support exchange processes over the range of kinetic regimes available for QM intermediates under neutral aqueous conditions.…”

Section: Resultsmentioning

confidence: 99%

A walk along DNA using bipedal migration of a dynamic and covalent crosslinker

Fakhari

Rokita

2014

Nat Commun

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DNA has previously served as an excellent scaffold for molecular transport based on its noncovalent base pairing to assemble both stationary and mobile elements. Use of DNA can now be extended to transport systems based on reversible covalent chemistry. Autonomous and bipedal-like migration of crosslinking within helical DNA is made possible by tandem exchange of a quinone methide intermediate. In this report, net transport is illustrated to proceed over 10 base pairs. This process is driven towards its equilibrium distribution of crosslinks and consumes neither the walker nor the track irreversibly. Successful migration requires an electron-rich quinone methide to promote its regeneration and a continuous array of nucleophilic sites along its DNA track. Accordingly, net migration can be dramatically influenced by the presence of noncanonical structures within duplex DNA as demonstrated with a backbone nick and extrahelical bulge.

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Section: Resultsmentioning

confidence: 99%

A walk along DNA using bipedal migration of a dynamic and covalent crosslinker

Fakhari

Rokita

2014

Nat Commun

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“…Recently, small-molecule walkers that feature coordination chemistry for foot-track binding interactions have also been studied. 49 …”

Section: Synthetic Small-molecule Walkersmentioning

confidence: 99%

Artificial molecular motors

et al. 2017

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Motor proteins are nature's solution for directing movement at the molecular level. The field of artificial molecular motors takes inspiration from these tiny but powerful machines. Although directional motion on the nanoscale performed by synthetic molecular machines is a relatively new development, significant advances have been made. In this review an overview is given of the principal designs of artificial molecular motors and their modes of operation. Although synthetic molecular motors have also found widespread application as (multistate) switches, we focus on the control of directional movement, both at the molecular scale and at larger magnitudes. We identify some key challenges remaining in the field.

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“…A few examples of artificial molecular rotary motors and DNA-based linear motors [21] have been described, and fully synthetic linear motor molecules are available [22,23] . Such systems, however, are based on sophisticated chemical species and/or their operation relies on a complex sequence of chemical reactions.…”

Section: Examples Relative Light-controlled Unidirectional Transit Ofmentioning

confidence: 99%

The eternal youth of azobenzene: new photoactive molecular and supramolecular devices

Baroncini

Ragazzon

Silvi

et al. 2015

Pure and Applied Chemistry

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The development of multicomponent chemical systems that can perform predetermined functions under external control -i.e., molecular devices -is a challenging task in chemistry and a fascinating objective in the frame of a bottom-up approach to nanostructures. Photochromic units undergo profound changes in their chemical and/or electronic structure upon light excitation, and are highly interesting for the construction of photocontrollable molecular devices, machines and materials. The E-Z photoisomerization of azobenzene -owing to its high efficiency, excellent reversibility and significant physico-chemical differences between the two forms -is a highly useful reaction in this regard. Azobenzene photoisomerization has been known for almost 80 years and has been exploited to implement light-induced functionalities with a large variety of compounds, biomolecules, nanosystems and materials. Here we present some of our recent investigations highlighting how this outstanding photochrome can be utilized to develop (supra)molecular systems with valuable light-induced functionalities.

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Toward Metal Complexes That Can Directionally Walk Along Tracks: Controlled Stepping of a Molecular Biped with a Palladium(II) Foot

Cited by 49 publications

References 82 publications

A walk along DNA using bipedal migration of a dynamic and covalent crosslinker

A walk along DNA using bipedal migration of a dynamic and covalent crosslinker

Artificial molecular motors

The eternal youth of azobenzene: new photoactive molecular and supramolecular devices

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