Toward in vivo nanoscale communication networks: utilizing an active network architecture

Bush, Stephen F.

doi:10.1007/s11704-011-0116-9

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…Furthermore, multiplexed data transmission via ultrasound is likely possible because of its short wavelength in tissue at reasonable carrier frequencies. It may also be of interest to explore network architectures (Bush, 2011) in which data is transmitted at low transmit power over short distances via local hops between neighboring nodes capable of signal restoration.…”

Section: Evaluation Of Modalitiesmentioning

confidence: 99%

Physical principles for scalable neural recording

Marblestone

Zamft

Maguire

et al. 2013

Front. Comput. Neurosci.

224

223

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Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, motivating an analysis of the fundamental physical constraints on the problem. We outline the physical principles governing brain activity mapping using optical, electrical, magnetic resonance, and molecular modalities of neural recording. Focusing on the mouse brain, we analyze the scalability of each method, concentrating on the limitations imposed by spatiotemporal resolution, energy dissipation, and volume displacement. Based on this analysis, all existing approaches require orders of magnitude improvement in key parameters. Electrical recording is limited by the low multiplexing capacity of electrodes and their lack of intrinsic spatial resolution, optical methods are constrained by the scattering of visible light in brain tissue, magnetic resonance is hindered by the diffusion and relaxation timescales of water protons, and the implementation of molecular recording is complicated by the stochastic kinetics of enzymes. Understanding the physical limits of brain activity mapping may provide insight into opportunities for novel solutions. For example, unconventional methods for delivering electrodes may enable unprecedented numbers of recording sites, embedded optical devices could allow optical detectors to be placed within a few scattering lengths of the measured neurons, and new classes of molecularly engineered sensors might obviate cumbersome hardware architectures. We also study the physics of powering and communicating with microscale devices embedded in brain tissue and find that, while radio-frequency electromagnetic data transmission suffers from a severe power–bandwidth tradeoff, communication via infrared light or ultrasound may allow high data rates due to the possibility of spatial multiplexing. The use of embedded local recording and wireless data transmission would only be viable, however, given major improvements to the power efficiency of microelectronic devices.

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Section: Evaluation Of Modalitiesmentioning

confidence: 99%

Physical principles for scalable neural recording

Marblestone

Zamft

Maguire

et al. 2013

Front. Comput. Neurosci.

224

223

View full text Add to dashboard Cite

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“… 115 Illustrates an example of that, it shows a titanium nitride antenna fabricated on sapphire substrate. This antenna is fed through surface mount, coplanar U.Fl connector, 116 which is adhered to titanium nitride with silver epoxy. This connector is connected to a 3 in.…”

Section: In‐vivo Antenna Architecturementioning

confidence: 99%

A survey on state of the inter body radio communication channel: Performance and solutions

Mezher¹,

Alabbas

Ilyas

2022

Trans Emerging Tel Tech

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The development of in-vivo communications and networking systems has the potential for improving the healthcare delivery while also enabling the creation of new services and applications. In-vivo communications provide wireless networked cyber-physical systems of the embedded devices that enable accurate, quick, and cost-effective responses under a variety of circumstances. Also, it is focused upon modeling and characterizing in-vivo wireless channel, as well as contrasting it to other well-known channels. In this paper, channel coding is also mentioned because it improves data rates and performance gain. This work also discusses present problems and potential research topics for in-vivo communications. This article aims to show the researchers how the orthogonal frequency multiple access (OFDMA) technique improved the performance of in-vivo channel and how it is outperformed compared to the other techniques (TDM, TDMA, CDMA and OFDM) also how the OFDMA outperformed equalizers and channel coding in terms of bit error rate with giving a significant improvement of data transmitting and avoiding inter symbol interference. However, when it comes to the in-vivo communications, the modeling of in-vivo wireless channel is vital.Understanding the features of the in-vivo channel is critical for achieving optimal processing and designing successful procedures that allow WBANs to be arranged inside the human body.

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“…Structural studies continue to provide an insider's view at the molecular scale but currently remain incomplete in resolution detail and provide static time points. Computational bioinformatics will help to bridge the gap between experiment, structure, and in vitro models as has been done to understand the role of tubulin C-terminal tails, 94 microtubule dynamics of tubulin polymerization/depolymerization, 60 mesoscale communication networks, 166 and in vitro models to test kinesin-microtubule functional and organizational plasticity. 52,167 As well, biomimicry is important to test and apply our understanding of kinesin-tubulin interactions.…”

Section: Future Directionsmentioning

confidence: 99%

The kinesin–tubulin complex: considerations in structural and functional complexity

Olmsted¹,

Colliver²,

Paluh³

2015

CHC

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The ability of cells to respond to external cues by appropriately manipulating their internal environment requires a dynamic microtubule cytoskeleton that is facilitated by associated kinesin motor interactions. The evolutionary adaptations of kinesins and tubulins when merged generate a highly adaptable communication and infrastructure cellular network that is important to understanding specialized cell functions, human disease, and disease therapies. Here, we review the state of the field in the complex relationship of kinesin-tubulin interactions. We propose 12 mechanistic specializations of kinesins. In one category, referred to as sortability, we describe how kinesin interactions with tubulin isoforms, isotypes, or posttranslationally modified tubulins contribute to diverse cellular roles. Fourteen kinesin families have previously been described. Here, we illustrate the great depth of functional complexity that is possible in members within a single kinesin family by mechanistic specialization through discussion of the well-studied Kinesin-14 family. This includes new roles of Kinesin-14 in regulating supramolecular structures such as the microtubule-organizing center γ-tubulin ring complex of centrosomes. We next explore the value of an improved mechanistic understanding of kinesin-tubulin interactions in regard to human development, disease mechanisms, and improving treatments that target kinesin-tubulin complexes. The ability to combine the current kinesin nomenclature along with a more precisely defined kinesin and tubulin molecular toolbox is needed to support more detailed exploration of kinesin-tubulin interaction mechanisms including functional uniqueness, redundancy, or adaptations to new roles upon cell specialization, and to thereby accelerate applications in human health.

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Toward in vivo nanoscale communication networks: utilizing an active network architecture

Cited by 6 publications

References 52 publications

Physical principles for scalable neural recording

Physical principles for scalable neural recording

A survey on state of the inter body radio communication channel: Performance and solutions

The kinesin–tubulin complex: considerations in structural and functional complexity

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Toward in vivo nanoscale communication networks: utilizing an active network architecture

Cited by 6 publications

References 52 publications

Physical principles for scalable neural recording

Physical principles for scalable neural recording

A survey on state of the inter body radio communication channel: Performance and solutions

The kinesin&ndash;tubulin complex: considerations in structural and functional complexity

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Product

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The kinesin–tubulin complex: considerations in structural and functional complexity