Toward improved accuracy in shear wave elastography of arteries through controlling the arterial response to ultrasound perturbation in-silico and in phantoms

Hugenberg, Nicholas; Roy, Tuhin; Harrigan, Hadiya; Capriotti, Margherita; Lee, Hyoung-Ki; Guddati, Murthy N.; Urban, Matthew W.; Aquino, Wilkins

doi:10.1088/1361-6560/ac38fe

Cited by 4 publications

(5 citation statements)

References 37 publications

(43 reference statements)

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“…Figures 14(c It is apparent that top wall moves in the opposite direction from walls at 90°and 270°. These motions show the symmetric mode along the circumference of tube and is very consistent with the circumferential mode (m=2) of our previous work (Hugenberg et al 2021).…”

Section: Circumferential Wavessupporting

confidence: 90%

“…The waves indicated by blue arrows will be referred to the circumferential wave, which will be examined later with the cross-sectional data from the Transducer #2. The waves in the dash-dotted red box can be considered as a symmetric mode from the waveguide model (Hugenberg et al 2021). The + and − signs represent the motion is larger and smaller than a DC component, respectively.…”

Section: Z Component Of Motion From the Longitudinal Viewmentioning

confidence: 99%

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Measurement of wave propagation through a tube using dual transducers for elastography in arteries

Lee¹,

Capron²,

Liu³

et al. 2022

Phys. Med. Biol.

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Objective. Measuring waves induced with acoustic radiation force (ARF) in arteries has been studied over the last decade. To date, it remains a challenge to quantitatively assess the local arterial biomechanical properties. The cylindrical shape and waveguide behavior of waves propagating in the arterial wall pose complexities to determining the mechanical properties of the artery. Approach. In this paper, an artery-mimicking tube in water is examined utilizing three-dimensional measurements. The cross-section of the tube is measured while a transducer is translated over 41 different positions along the length of the tube. Motion in the radial direction is calculated using two components of motion which are measured from the two orthogonal views of the cross-section. This enables more accurate estimation of motion along the circumference of tube. Main results. The results provide more information to categorize the motion in tube wall into two types of responses: a transient response and a steady state response. The transient response is caused by ARF application and the waves travel along the length of the tube for a relatively short period of time. This corresponds to the axial and circumferential propagating waves. The two circumferential waves travel along the circumference of tube in CW (clockwise) and CCW (counter-clockwise) direction and result in a standing wave. By using a directional filter, the two waves were successfully separated, and their propagation was more clearly visualized. As a steady state response, a circumferential mode is generated showing a symmetric motion (i.e., the proximal and distal walls move in the opposite direction) following the transient response. Significance. This study provides a more comprehensive understanding of the waves produced in an artery-mimicking tube with ARF application, which will provide opportunities for improving measurement of arterial mechanical properties.

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Section: Circumferential Wavessupporting

confidence: 90%

Section: Z Component Of Motion From the Longitudinal Viewmentioning

confidence: 99%

Measurement of wave propagation through a tube using dual transducers for elastography in arteries

Lee¹,

Capron²,

Liu³

et al. 2022

Phys. Med. Biol.

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show abstract

“…This study shows that it is possible to select the modes induced by a source, controlling the loading angle, hence different loading conditions affect the spectral response of the waveguide in terms of mode content. The work in Hugenberg et al (2021) demonstrates such tuning capability with analytical guided wave theory and numerical simulations, and anticipates similar results.…”

Section: Hollow Cylinder Guided Wavessupporting

confidence: 68%

“…The bandwidth of the propagating waves in arterial walls is important because we seek to use the wave velocity dispersion curves (phase velocity variation with frequency) to fit to waveguide models to solve for the mechanical properties of the artery (Astaneh et al 2017. Recently, we studied the theory behind the selection of modes controlling the shape of the push beam (Hugenberg et al 2021).…”

Section: Introductionmentioning

confidence: 99%

The influence of acoustic radiation force beam shape and location on wave spectral content for arterial dispersion ultrasound vibrometry

Capriotti¹,

Roy²,

Hugenberg³

et al. 2022

Phys. Med. Biol.

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Objective: Arterial dispersion ultrasound vibrometry (ADUV) relies on the use of guided waves in arterial geometries for shear wave elastography measurements. Both the generation of waves through the use of acoustic radiation force (ARF) and the techniques employed to infer the speed of the resulting wave motion affect the spectral content and accuracy of the measurement. In particular, the effects of the shape and location of the ARF beam in ADUV have not been widely studied. In this work, we investigated how such variations of the ARF beam affect the induced motion and the measurements in the dispersive modes that are excited. Approach: The study includes an experimental evaluation on an arterial phantom and an in vivo validation of the observed trends, observing the two walls of the waveguide, simultaneously, when subjected to variations in the ARF beam extension (F/N) and focus location. Main Results: Relying on the theory of guided waves in cylindrical shells, the shape of the beam controls the selection and nature of the induced modes, while the location affects the measured dispersion curves (i.e., variation of phase velocity with frequency or wavenumber, multiple modes) across the waveguide walls. Significance: This investigation is important to understand the spectral content variations in ADUV measurements and to maximize inversion accuracy by tuning the ARF beam settings in clinical applications.

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“…This type of problem arises in numerous applications, such as non-destructive evaluation of pipes and ultrasound elastography of arteries . Figure 2 shows a waveguide configuration typically found in ultrasound-based dispersion vibrometry (Bernal et al 2011, Hugenberg et al 2021, Capriotti et al 2022.…”

Section: Stochastic Parameter Inversion Using Waveguide Modelsmentioning

confidence: 99%

Generalized Bayes approach to inverse problems with model misspecification

Baek,

Aquino,

Mukherjee

2023

Inverse Problems

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We propose a general framework for obtaining probabilistic solutions to PDE-based inverse problems. Bayesian methods are attractive for uncertainty quantification but assume knowledge of the likelihood model or data generation process. This assumption is difficult to justify in many inverse problems, where the specification of the data generation process is not obvious. We adopt a Gibbs posterior framework that directly posits a regularized variational problem on the space of probability distributions of the parameter. We propose a novel model comparison framework that evaluates the optimality of a given loss based on its ‘predictive performance’. We provide cross-validation procedures to calibrate the regularization parameter of the variational objective and compare multiple loss functions. Some novel theoretical properties of Gibbs posteriors are also presented. We illustrate the utility of our framework via a simulated example, motivated by dispersion-based wave models used to characterize arterial vessels in ultrasound vibrometry.

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Toward improved accuracy in shear wave elastography of arteries through controlling the arterial response to ultrasound perturbation in-silico and in phantoms

Cited by 4 publications

References 37 publications

Measurement of wave propagation through a tube using dual transducers for elastography in arteries

Measurement of wave propagation through a tube using dual transducers for elastography in arteries

The influence of acoustic radiation force beam shape and location on wave spectral content for arterial dispersion ultrasound vibrometry

Generalized Bayes approach to inverse problems with model misspecification

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